2016-2022年南京市新报告≥18岁学生HIV感染者区域分子传播特征分析  

Regional molecular transmission characteristics of newly reported HIV-infected students aged≥18 years in Nanjing City from 2016 to 2022

作　　者：时红杰 王赛男 李昕[1] 吴苏姝[1] 伍蓉 袁欣 王静文 沈小勇 徐园园[1] 朱正平[1] Shi Hongjie;Wang Sainan;Li Xin;Wu Sushu;Wu Rong;Yuan Xin;Wang Jingwen;Sheng Xiaoyong;Xu Yuanyuan;Zhu Zhengping(Department of AIDS/STD Control and Prevention,Nanjing Municipal Center for Disease Control and Prevention,Nanjing 210003,China;Department of Laboratory Medicine,Jiangning Hospital Affiliated to Nanjing Medical University,Nanjing 211100,China;Public Health Division,Tuqiao Community Hospital,Jiangning District,Nanjing 211100,China)

机构地区：[1]南京市疾病预防控制中心艾滋病性病防制科,南京210003 [2]南京市江宁医院检验科,南京211100 [3]南京市江宁区土桥社区医院公共卫生科,南京211100

出　　处：《中华预防医学杂志》2025年第1期82-89,共8页Chinese Journal of Preventive Medicine

基　　金：江苏省社科应用研究精品工程课题(23SYC-007);2023年度开放课题经费资助(JSHD202329);江苏省科教能力提升工程专项经费资助(ZDXYS202210);南京市卫生科技发展专项资金项目(ZKX23059,YKK23192);南京市疾病预防控制中心青年人才科研培育团队项目(NPY2307);南京医科大学公共卫生学院强基计划(NQJ2301);南京市重点医学专科项目(传染病控制专科)。

摘　　要：分析南京市2016—2022年新报告≥18岁学生人类免疫缺陷病毒(HIV)感染者传播特征,为学生开展艾滋病宣传干预提供依据。整合2016—2022年南京新报告HIV学生感染者和非学生HIV感染者pol区序列,使用BLAST工具搜索LANL HIV database中公开发表的全球非南京报告感染者序列;使用HIV-TRACE工具在1.0%的成对基因距离阈值下分别构建基础分子传播网络和区域分子传播网络。成功获取南京≥18岁学生感染者序列332条,南京非学生感染者序列1904条,非南京报告感染者序列1698条。332例学生感染者中,感染途径以同性传播为主(96.39%),亚型以CRF01_AE(37.95%)、CRF07_BC(37.65%)和CRF105_0107(10.24%)为主。区域分子传播网络共有890条序列,其中南京学生感染者序列占21.80%,南京报告的非学生感染者序列占39.89%,非南京报告感染者序列占38.31%。CRF105_0107传播簇内感染者中南京报告的非学生感染者占66.95%(81/121),CRF07_BC传播簇非南京报告感染者占56.66%(200/353)。区域分子传播网络内与学生感染者相连接的边数共1644条,本地传播占64.72%,区域传播占35.28%,区域传播以广东省(19.83%)和江苏省其他市(4.50%)为主。综上,南京市≥18岁新报告学生HIV病例HIV-1亚型以CRF01_AE、CRF07_BC和CRF105_0107为主,传播特征以本地传播为主;存在学生与非学生间传播。To analyze the transmission characteristics of newly reported HIV-infected students aged≥18 years in Nanjing City from 2016 to 2022 and provide evidence for AIDS publicity and intervention among young students.The pol region sequences of newly reported HIV-infected students and non-student HIV-infected individuals in Nanjing City from 2016 to 2022 were collected,and the BLAST tool was used to search the published global non-Nanjing reported HIV infection sequences in the LANL HIV database.The basic molecular transmission network and regional molecular transmission network were constructed using the HIV-TRACE in a pairwise genetic distance threshold of 1.0%.332 sequences of infected students aged≥18 years in Nanjing City,1904 sequences of non-student-infected individuals in Nanjing City and 1698 non-Nanjing-infected individuals were obtained.Among the 332 infected students,the main route of infection was homosexual(96.39%),and the subtypes were CRF01_AE(37.95%),CRF07_BC(37.65%)and CRF105_0107(10.24%).There were 890 sequences in the regional molecular transmission network,of which 21.80%were infected students in Nanjing City,39.89%were non-student-infected individuals in Nanjing City,and 38.31%were non-Nanjing-infected individuals.In the CRF105_0107 transmission cluster,non-student-infected individuals from Nanjing accounted for 66.95%(81/121),while in the CRF07_BC transmission cluster,non-Nanjing-infected individuals accounted for 56.66%(200/353).There were 1644 edges connected to infected students within the regional molecular transmission network,with local transmission accounting for 64.72%and regional transmission accounting for 35.28%.Regional transmission was mainly in Guangdong Province(19.83%)and other cities in Jiangsu Province(4.50%).The HIV-1 subtypes of newly reported HIV-infected students aged≥18 years in Nanjing City are mainly CRF01_AE,CRF07_BC and CRF105_0107,with local transmission as the main transmission characteristics.There is transmission between students and non-students.

关 键 词：人类免疫缺陷病毒 横断面研究 分子传播网络 区域传播 

分 类 号：R512.91[医药卫生—内科学] R181.3[医药卫生—临床医学]