“导气同精”针法治疗肾精不足型老年性耳聋的疗效研究及其对血清白细胞介素-6、白细胞介素-10水平的影响  

Study on the therapeutic effect of the“Qi-Guiding and Essence-Tonifying”acupuncture method on age-related hearing loss with kidney essence deficiency syndrome and its impact on serum interleukin-6 and interleukin-10 levels

作　　者：童艳 刘赟[2] 王磊 顾丹妮 陈伟伦 吴生兵[3] Tong Yan;Liu Yun;Wang Lei;Gu Danni;Chen Weilun;Wu Shengbing(Wuxi Xinwu District Traditional Chinese Medicine Hospital,Wuxi Jiangsu 214026;Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine,Wuxi Jiangsu 214071;Anhui University of Chinese Medicine,Hefei Anhui 230038)

机构地区：[1]无锡市新吴区中医医院,江苏无锡214026 [2]南京中医药大学无锡附属医院,江苏无锡214071 [3]安徽中医药大学,安徽合肥230038

出　　处：《山西中医药大学学报》2025年第1期46-52,共7页Journal of Shanxi University of Chinese Medicine

基　　金：国家自然科学基金资助项目(81273858);无锡市中医药管理局科技项目(ZYYB02)。

摘　　要：目的:观察“导气同精”针法治疗肾精不足型老年性耳聋(ARHL)的临床疗效及其对血清白细胞介素-6(IL-6)、白细胞介素-10(IL-10)水平的影响。方法:将60例肾精不足型ARHL患者随机分为常规针刺组和导气同精针刺组,每组30例。常规针刺组采用常规针刺治疗。导气同精针刺组行导气同精手法,1次/d,10次为1个疗程。两组患者连续治疗4个疗程后,评价其临床疗效,观察两组患者治疗前后平均听阈、耳鸣严重程度评分、简易智能精神状态检查量表(MMSE)、生活质量量表(SF-36)评分以及患者血清IL-6、IL-10水平变化情况。结果:(1)导气同精针刺组治疗总有效率66.67%(20/30)高于常规针刺组总有效率36.67%(11/30),差异有统计学意义(P<0.05)。(2)治疗后,两组患者的平均听阈值明显提高,且与常规针刺组相比,导气同精针刺组对平均听阈值改善更加明显,差异有统计学意义(P<0.05)。(3)治疗后,两组患者耳鸣严重程度评分均明显降低,且导气同精针刺组降低更明显,差异有统计学意义(P<0.05)。(4)治疗后,两组患者MMSE量表评分均得到一定程度的提高,且导气同精针刺组提高更明显,差异有统计学意义(P<0.05)。(5)治疗后,两组患者SF-36量表评分明显提高,且导气同精针刺组评分提高更明显,差异有统计学意义(P<0.05)。(6)治疗后,两组患者血清中IL-6水平下降,IL-10水平上升,其中导气同精针刺组对血清中IL-6、IL-10水平调节明显优于常规针刺组,差异有统计学意义(P<0.05)。结论:导气同精针法可以明显提高肾精不足型ARHL患者的临床疗效及平均听阈,改善患者的听力水平及耳鸣症状,同时还可以调节血清炎症因子IL-6、IL-10水平,提高患者认知能力,改善生活质量,值得研究和临床推广。Objective:To observe the clinical efficacy of the“Qi-Guiding and Essence-Tonifying”acupuncture method in treating age-related hearing loss(ARHL)with kidney essence deficiency syndrome and its impact on serum interleukin-6 and interleukin-10 levels.Methods:Sixty patients with ARHL with kidney essence deficiency syndrome were randomly divided into conventional acupuncture group and Qi-Guiding and Essence-Tonifying acupuncture group,with 30 cases in each group.Patients in the conventional acupuncture group were treated with conventional acupuncture.Patients in Qi-Guiding and Essence-Tonifying acupuncture group underwent guiding Qi and tonifying essence acupuncture,once/d,10 times for 1 course of treatment.After 4 consecutive courses of treatment,the clinical efficacy of the two groups was evaluated.The average hearing threshold,tinnitus severity score,Mini Mental State Examination(MMSE),Quality of Life Scale(SF-36)scores,and changes in serum interleukin-6(IL-6)and interleukin-10(IL-10)levels were observed in the two groups before and after treatment.Results:(1)The total effective rate of the Qi-Guiding and Essence-Tonifying acupuncture group was 66.67%(20/30),which was higher than 36.67%(11/30)of the conventional acupuncture group,and the difference was statistically significant(P<0.05).(2)After treatment,the average hearing threshold of the two groups significantly increased.Compared with that of the conventional acupuncture group,the average hearing threshold of the Qi-Guiding and Essence-Tonifying acupuncture group was improved more obviously,and the difference was statistically significant(P<0.05)(.3)After treatment,the severity scores of tinnitus in both groups were significantly reduced,with the Qi-Guiding and Essence-Tonifying acupuncture group showing a more significant decrease.The difference was statistically significant(P<0.05).(4)After treatment,the MMSE scores of the two groups were improved to a certain extent.The Qi-Guiding and Essence-Tonifying acupuncture group improved more obviously,and the di

关 键 词：老年性耳聋 导气同精 肾精不足 SF-36 临床观察 

分 类 号：R764.436[医药卫生—耳鼻咽喉科]