Cognitive decline in relation to later-life high temperature exposure in a Chinese nationwide cohort  

作　　者：Yu-Qian HANG Lian-Sheng ZHANG Ji-Xing YANG Fang WANG Ya-Qi WANG Li-Feng ZHU Yuan-Yuan ZHANG Bo-Ning DENG Qian-Qian XIANG Yun-Quan ZHANG 

机构地区：[1]Institute of Social Development and Health Management,Hubei Province Key Laboratory of Occupational Hazard Identification and Control,School of Public Health,Wuhan University of Science and Technology,Wuhan 430065,China [2]School of Public Health,Xiangnan University,Chenzhou 423001,China [3]School of Public Health,Xuzhou Medical University,Xuzhou 221004,China [4]Wuhan Center for Disease Control and Prevention,Wuhan 430022,China [5]School of Medicine,Wuhan University of Science and Technology,Wuhan 430065,China [6]Hubei Provincial Center for Disease Control and Prevention,Wuhan 430079,China

出　　处：《Advances in Climate Change Research》2024年第6期1078-1087,共10页气候变化研究进展(英文版)

基　　金：supported by Social Sciences General Project of Hubei Provincial Department of Education(23Y152);Wuhan Knowledge Innovation Project(2023020201020410&2023020201020564);The 14th Five Year Plan Hubei Provincial Advantaged Characteristic Disciplines(Groups)Project of Wuhan University of Science and Technology(2023C0102).

摘　　要：Growing evidence has linked extreme temperature with neuropsychiatric disorders under climate warming with frequent extreme heat events over the past decades,while cognitive performance in relation to heat exposure remains largely unstudied,particularly in populations at high vulnerability to climate risks(e.g.,China).Based on five survey waves of a nationwide dynamic cohort(2011–2020),we analyzed 47,825 cognitive test records from 14,729 respondents aged 45+years across 126 Chinese cities.Global cognitive performance and its two dimensions(episodic memory and mental status)was measured using standardized questionnaires.Temperature exposure prior to cognitive tests was assessed using both average temperatures and heat days exceeding predefined temperature thresholds.Linear mixed-effects models were utilized to examine the relationship between high temperature exposure and cognitive function.This study revealed consistent evidence for heat-related declines in global cognitive performance and episodic memory across multiple exposure-window analyses,while robust associations were observed solely during prolonged exposure periods(more than 90 d)for mental status.For each 1-℃ rise in annual mean temperature within 1 year prior to investigation,cognitive scores declined by 0.058(95%CI:−0.079,−0.037)points for global performance,0.033(95%CI:−0.048,−0.018)points for episodic memory,and 0.025(95%CI:−0.038,−0.013)points for mental status,respectively.Similar findings were seen in analyses using heat exposure days defined by multiple temperature percentiles,linking per 10-d increase in heat duration to reduced global cognitive scores ranging from−0.142(95%CI:−0.214,−0.070)to−0.168(95%CI:−0.254,−0.082).Despite varied evidence by heat exposure metrics and cognitive dimensions,stratified analyses suggested possibly higher susceptibility among females,less-educated,and urban-dwelling residents to heat-related cognitive impairment.These results provided suggestive evidence for the role of exposure to

关 键 词：High temperature Heat exposure Cognitive function Middle-aged and older adults CHARLS 

分 类 号：P467[天文地球—大气科学及气象学]