中医药调控中性粒细胞胞外诱捕网机制防治代谢性疾病的研究进展  

Research progress on mechanism of traditional Chinese medicine in regulating neutrophil extracellular traps in prevention and treatment of metabolic diseases

作　　者：张赛 樊明媛 袁久术 姚淇元 谢红艳[1,2] 袁海泼 高泓[1,2] ZHANG Sai;FAN Ming-yuan;YUAN Jiu-shu;YAO Qi-yuan;XIE Hong-yan;YUAN Hai-po;GAO Hong(Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610072,China;TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province,Chengdu 610075,China)

机构地区：[1]成都中医药大学附属医院,四川成都610072 [2]代谢性疾病中医药调控四川省重点实验室,四川成都610075

出　　处：《中国中药杂志》2025年第1期78-92,共15页China Journal of Chinese Materia Medica

基　　金：第五批全国中医临床优秀人才研修项目(H2022037);四川省中医药管理局项目(2024ZD002,2024MS548);四川省自然科学基金项目(2024NSFSC1855)。

摘　　要：代谢性疾病近年来发病率稳步上升,已成为全球亚健康状态的主要原因之一。中性粒细胞胞外诱捕网(NETs)是一种包含DNA的网状复合物,并以此为基质诱捕外来微生物或诱导免疫反应。当前研究表明,NETs广泛活跃于多种代谢性疾病中,并通过促进血糖升高、损伤血管内皮细胞、形成血管栓塞、激发剧烈炎症、促进脂质堆积累等多种方式对机体造成严重损害,因此干预NETs是治疗代谢性疾病的一个重要途径。研究发现,脾瘅-浊毒理论与代谢性疾病-NETs机制有着紧密联系,其基本病机为痰湿内蕴、气滞血瘀、湿热内蕴、痰瘀互结、热毒内盛等,而多种具有祛湿、化痰、活血化瘀、清热解毒功效的中药及其提取物和复方可通过调节NETs治疗代谢性疾病,延缓病程进展。该文详细梳理了NETs形成机制、与代谢性疾病的联系、中医理论依据、在众多代谢性疾病中的作用,以及当前中医药调控NETs防治代谢性疾病的研究现状,旨在为代谢性疾病开发治疗手段提供有效参考思路。Metabolic diseases have seen a steady increase in incidence in recent years,becoming one of the main causes of sub-health status globally.Neutrophil extracellular traps(NETs)are reticular complexes containing DNA,which trap foreign microorganisms or induce an immune response.Current research indicates that NETs are widely active in various metabolic diseases and can cause severe damage to the body through multiple mechanisms,including promoting blood glucose elevation,damaging vascular endothelial cells,forming vascular embolisms,triggering intense inflammation,and promoting lipid accumulation.Therefore,intervening in NETs is an important approach to treating metabolic diseases.Research has shown a close relationship between the theory of spleen heat-turbid toxin theory and metabolic diseases-NETs mechanism.The basic pathogenesis include the internal accumulation of phlegm-dampness,qi stagnation and blood stasis,internal accumulation of dampness-heat,phlegm and blood stasis,and flourishing toxic heat.Various Chinese herbal medicines with the functions of dispelling dampness,resolving phlegm,promoting blood circulation to remove blood stasis,and clearing heat and toxins,along with their extracts and compound prescriptions,can treat metabolic diseases by regulating NETs and delaying disease progression.This paper systematically outlined the formation mechanisms of NETs,their connection to metabolic diseases,the theoretical basis in TCM,their roles in numerous metabolic diseases,and the current research status of TCM in regulating NETs to prevent and control metabolic diseases,aiming to provide effective reference ideas for developing therapeutic strategies for metabolic diseases.

关 键 词：代谢性疾病 中性粒细胞胞外诱捕网 中医药 脾瘅 浊毒 研究进展 

分 类 号：R285[医药卫生—中药学]