PM_(2.5)及其组分短期暴露对空腹血糖和血脂的影响  

Effects of short-term exposure to PM_(2.5)and its constituents on fasting plasms glucose and blood lipids

作　　者：桑晨 贺颖倩 贾佳 陈浩 王敏珍[1] SANG Chen;HE Ying-qian;JIA Jia;CHEN Hao;WANG Min-zhen(Institute of Epidemiology and Statistics,School of Public Health,Lanzhou University,Lanzhou 730000,China;Yuzhong District Center for Disease Control and Prevention,Chongqing 400000,China)

机构地区：[1]兰州大学公共卫生学院,流行病与卫生统计学研究所,甘肃兰州730000 [2]重庆市渝中区疾病预防控制中心,重庆400000

出　　处：《中国环境科学》2025年第2期1118-1126,共9页China Environmental Science

基　　金：甘肃省杰出青年基金(23JRRA1019);河北省糖尿病基础医学研究重点实验室开放课题(KF2023-02)。

摘　　要：为探究PM_(2.5)及其组分(SO_(4)^(2-)、NO_(3)^(-)、NH_(4)^(+)、OM和BC)短期暴露对人群空腹血糖和血脂的影响,以“金昌队列”为研究平台,从中国大气成分近实时追踪数据集获取金昌市2011~2015年PM_(2.5)及组分日均浓度数据.通过将研究对象家庭住址经纬度信息与污染物数据匹配,以评估个体污染物暴露水平.采用广义估计方程分析PM_(2.5)及其组分短期暴露对糖脂指标的影响.运用广义相加混合模型绘制暴露-反应关系曲线,并进行分层分析.结果显示,PM_(2.5)及其组分(SO_(4)^(2-)、NO_(3)^(-)、NH_(4)^(+)、OM和BC)对人群血糖和血脂水平的影响存在一定的滞后效应,随着PM_(2.5)、SO_(4)^(2-)、NO_(3)^(-)、NH_(4)^(+)、OM浓度的升高,FPG、TC、HDL-C和LDL-C呈上升趋势,TG呈下降趋势.PM_(2.5)和SO_(4)^(2-)对男性人群的空腹血糖水平影响更显著;PM_(2.5)及其五种组分对女性、年龄≥60岁、超重或肥胖、处于糖尿病前期及患高血压人群的血脂水平影响更显著.因此,PM_(2.5)及其组分的短期暴露与人群血糖和血脂水平异常相关,不同高风险人群需加强自我防护措施.The effects of PM_(2.5)and its constituents(SO_(4)^(2-),NO_(3)^(-),NH_(4)^(+),OM,BC)on fasting blood glucose and lipid levels in the short-term were examined in the“Jinchang Cohort”.The daily average concentrations of PM_(2.5)and its constituents from 2010to 2015 in Jinchang City were sourced from China's Near Real-Time Air Pollutants dataset.Individual exposure was determined by matching the study subjects'residential addresses with pollution data.Generalized estimating equations were used to analyze the short-term effects of PM_(2.5)and its constituents on glucose and lipid indicators.Generalized additive mixed models were used to create exposure-response curves and perform stratified analyses.The findings showed that PM_(2.5)and its constituents had delayed effects on blood glucose and lipid levels.Specifically,higher concentrations of PM_(2.5),SO_(4)^(2-),NO_(3)^(-),NH_(4)^(+),and OM correlated with increased levels of FPG,TC,HDL-C,and LDL-C,while TG showed a decrease.PM_(2.5)and SO_(4)^(2-)exhibited more pronounced effects on fasting blood glucose levels in males,whereas PM_(2.5)and its five components had more significant impacts on lipid levels in females,individuals aged 60 years or older,those who are overweight or obese,individuals in prediabetic stages,and those with hypertension.Therefore,short-term exposure to PM_(2.5)and its components correlates with abnormal blood glucose and lipid levels in the population.Thus,various high-risk groups should adopt self-protection measures accordingly.

关 键 词：PM_(2.5)及组分 2型糖尿病 空腹血糖 血脂 队列研究 

分 类 号：X503[环境科学与工程—环境工程]