Role of immunomodulatory probiotics in alleviating bacterial diarrhea in piglets:a systematic review  

作　　者：Sudeb Saha Fu Namai Keita Nishiyama Julio Villena Haruki Kitazawa 

机构地区：[1]Food and Feed Immunology Group,Laboratory of Animal Food Function,Graduate School of Agricultural Science,Tohoku University,Sendai 980‑8572,Japan [2]Department of Dairy Science,Faculty of Veterinary,Animal and Biomedical Sciences,Sylhet Agricultural University,Sylhet 3100,Bangladesh [3]Livestock Immunology Unit,International Education and Research Center for Food and Agricultural Immunology(CFAI),Tohoku University,Sendai 980‑8572,Japan [4]Laboratory of Immunobiotechnology,Reference Centre for Lactobacilli(CERELA-CONICET),4000 Tucuman,CP,Argentina

出　　处：《Journal of Animal Science and Biotechnology》2024年第6期2175-2199,共25页畜牧与生物技术杂志(英文版)

基　　金：supported by Grants-in-Aid for Scientific Research(A)(19H00965,23H00354 HK);Grant-in-Aid for Scientific Research(B)(23H02358,KN);Grant-in-Aid for Research Activity Start-up(23K19327,FN);Challenging Research(Exploratory,23K18072,HK);JSPS Fellows(22F22080,HK)from the Japan Society for the Promotion of Science(JSPS);supported by the Research Program on Development of Innovative Technology Grants(JPJ007097)from the Project of the Bio-Oriented Technology Research Advancement Institution(BRAIN)and by the Japan Racing Association to HK;supported by the JSPS Core-to-Core Program,A.Advanced Research Networks,titled Establishment of the International Agricultural Immunology Research Core for Quantum Improvement in Food Safety。

摘　　要：Diarrhea is a common enteric disease in piglets that leads to high mortality and economic losses in swine production worldwide.Antibiotics are commonly used to prevent or treat diarrhea in piglets.However,irrational antibiotic use contributes to the development of resistance in bacteria and antibiotic residues in animal products,threatening public health,while causing gut microbiota dysbiosis and antibiotic-resistant bacterial infection in piglets.Therefore,the quest for alternative products(such as probiotics,prebiotics,organic acids,enzymes;essential oils,medium-chain fatty acids,zinc,and plant extracts)has recently been clearly emphasized through the increase in regulations regarding antibiotic use in livestock production.These antibiotic alternatives could lower the risk of antibiotic-resistant bacteria and meet consumer demand for antibiotic-free food.Several antibiotic alternatives have been proposed,including immunomodulatory probiotics,as candidates to reduce the need for antimicrobial therapy.Many studies have revealed that probiotics can avert and cure bacterial diarrhea by regulating the gut function and immune system of piglets.In this review,we focus on the major pathogenic bacteria causing piglet diarrhear the research sta of using probiotics to prevent and treat diarrhea,their possible mechanisms,and the safety issues related to the use of probiotics.Supplementation with probiotics is a possible alternative to antibiotics for the prevention or treatment of bacterial diarrhea in piglets.Furthermore,probiotics exe rt beneficial effects on feed efficiency and growth performance of piglets.Therefore,appropriate selection and strategies for the use of probiotics may have a positive effect on growth performance and also reduce diarrhea in piglets.This review provides useful information on probiotics for researchers,pig nutritionists,and the additive industry to support their use against bacterial,diarrhea in piglets.

关 键 词：CLOSTRIDIUM DIARRHEA E.COLI Immunomodulatory effect PIGLETS PROBIOTICS 

分 类 号：S858.28[农业科学—临床兽医学]