二氧化碳点阵激光联合生长因子外用对痤疮瘢痕局部皮肤生理功能及美容效果的影响  

The effect of CO_(2)dot matrix laser combined with growth factor topical application on the local skin physiological function and cosmetic effect of acne scars

作　　者：刘蕊[1] 翟炜 LIU Rui;ZHAI Wei(Radiology Intervention Room,Nanyang 473000,Henan Province,China;Dermatology Department,Nanyang Central Hospital,Nanyang 473000,Henan Province,China)

机构地区：[1]南阳市中心医院放射介入室,河南南阳473000 [2]南阳市中心医院皮肤科,河南南阳473000

出　　处：《中国医疗美容》2025年第1期13-17,共5页China Medical Cosmetology

摘　　要：目的观察二氧化碳(CO_(2))点阵激光联合生长因子外用对痤疮瘢痕局部皮肤生理功能及美容效果的影响。方法选取2022年1月至2024年8月南阳市中心医院收治的84例痤疮瘢痕患者为研究对象,根据治疗方法不同将其分为对照组(42例)和观察组(42例),对照组患者实施CO_(2)点阵激光照射,观察组患者在对照组基础上联合给予生长因子外用,应用3个月,分别在应用前后,评价瘢痕局部皮肤生理功能、美容效果;比较两组局部皮肤疼痛持续时间、红斑持续时间、皮肤结痂时间、痂皮脱落时间等皮肤症状。结果治疗前,两组患者痤疮瘢痕局部皮肤经皮水分丢失量、角质层蛋白质含量、角质层含水量、皮肤油脂溢量等皮肤生理功能,皮肤屏障及痤疮瘢痕权重(ECCA)评分、皮肤黑素指数评分,组间差异无统计学意义(P>0.05);治疗后,观察组患者皮肤生理功能明显优于对照组,ECCA评分、皮肤黑素指数评分,组间差异均有统计学意义(P<0.05)。观察组患者局部皮肤疼痛持续时间、红斑持续时间、皮肤结痂时间、痂皮脱落时间短于对照组,差异有统计学意义(P<0.05)。结论CO_(2)点阵激光联合生长因子外用对痤疮瘢痕局部皮肤生理功能具有明显改善作用,可有效缩短皮肤不适症状持续时间,提升美容效果。Objective To observe the effects of CO_(2)fractional laser combined with topical growth factor on local skin physiological functions and cosmetic outcomes in acne scars.Methods Eighty four patients with acne scar treated in Nanyang Central Hospital from January 2022 to August 2024 were selected as the research objects,and they were divided into the control group(42 cases)and the observation group(42 cases)according to the different treatment methods.The patients in the control group were treated with CO_(2)dot matrix laser irradiation,and the patients in the observation group were treated with growth factor for external use on the basis of the control group,which was applied for 3 months.Before and after the application,the local skin physiological function and cosmetic effect of the scar were evaluated;The local skin pain duration,erythema duration,skin crusting time,scab shedding time and other skin symptoms were compared between the two groups.Results fiBefore treatment,there were no significant differences between the two groups in terms of transepidermal water loss,stratum corneum protein content,stratum corneum hydration,sebum excretion,skin barrier function,ECCA score,and skin melanin index score(P>0.05).After treatment,the skin physiological functions of the observation group fiwere significantly better than those of the control group,with significant differences in ECCA scores and skin melanin index scores between the groups(P<0.05).The durations of local skin pain,erythema,crusting,and desquamation were shorter in the observation figroup than in the control group,with statistically significant differences(P<0.05).Conclusions The combination of CO_(2)fractional laser and topical growth factor has a notable improvement effect on local skin physiological functions in acne scars,effectively shortening the duration of skin discomfort symptoms.Enhance beauty outcomes.

关 键 词：CO_(2)点阵激光 生长因子 皮肤生理功能 美容效果 

分 类 号：R75[医药卫生—皮肤病学与性病学]