中国中老年人可能肌少症与衰弱发生风险关联的队列研究  

Association between possible sarcopenia and risk for frailty in middle-aged and elderly adults in China:a cohort study

作　　者：蒋安琪 魏玥 梁博 裴丽君[1] Jiang Anqi;Wei Yue;Liang Bo;Pei Lijun(Institute of Population Research/Chinese Center for Population Health and Development,Peking University,Beijing 100871,China)

机构地区：[1]北京大学人口研究所/北京大学中国人口健康与发展研究中心,北京100871

出　　处：《中华流行病学杂志》2025年第1期81-86,共6页Chinese Journal of Epidemiology

基　　金：国家重点研发计划(2018YFC2000603);国家自然科学基金(41871360)。

摘　　要：目的探讨中国中老年人可能肌少症与衰弱发生风险的关联。方法利用2011-2018年中国健康与养老追踪调查数据,采用前瞻性队列研究,以2011年9007名未发生衰弱的中老年人作为基线人群,分别于2013、2015、2018年随访衰弱结局。使用衰弱指数评价中老年人的衰弱状况,通过测量握力和重复5次起坐时间判断可能肌少症。采用Cox比例风险回归模型分析中老年人可能肌少症与衰弱发生风险的关联。结果共随访44884人年,发生衰弱586名,发病密度为13.06/1000人年。年龄≥60岁(HR=2.05,95%CI:1.71~2.45)、文化程度为小学以下(HR=1.55,95%CI:1.29~1.85)、腰高比≥0.5(HR=1.39,95%CI:1.11~1.75)和有抑郁情绪(HR=1.52,95%CI:1.28~1.81)使中老年人衰弱发生风险增加;有饮酒习惯可能降低衰弱发生风险(HR=0.76,95%CI:0.62~0.94)。患有可能肌少症使中老年人衰弱发生风险增加(HR=1.73,95%CI:1.47~2.05)。结论中国中老年人患有可能肌少症、年龄偏高、文化程度较低、中心性肥胖和有抑郁情绪会增加其衰弱发生风险,针对潜在的高危人群应尽早采取干预措施,延缓衰弱的发生发展。Objective To assess the association between possible sarcopenia and the risk for frailty in middle-aged and elderly adults in China.MethodsA prospective cohort study design was used in this study.Data were from the China Health and Retirement Longitudinal Study during 2011-2018 and the baseline data in 2011,the follow up was conducted in 2013,2015 and 2018,respectively.Frailty index was used to evaluate frailty status,and grip strength and repetitive sitting-up time were measured to detect possible sarcopenia.Cox proportional hazards regression model was used to estimate the association between possible sarcopenia and the risk for frailty in middle-aged and older adults.ResultsIn a 44884 person-years follow-up,a total of 586 cases with frailty were recorded,and the incidence density of frailty was 13.06 per 1000 person-year.The risk for frailty was also higher in those who were aged 60 years and above(HR=2.05,95%CI:1.71-2.45),had a primary school education level or below(HR=1.55,95%CI:1.29-1.85),had waist-to-height ratio≥0.5(HR=1.39,95%CI:1.11-1.75)and had depression(HR=1.52,95%CI:1.28-1.81).Drinking was associated with reduced risk for frailty(HR=0.76,95%CI:0.62-0.94).The risk for frailty increased(HR=1.73,95%CI:1.47-2.05)in those who might has possible sarcopenia.ConclusionsIn middle-aged and elderly adults,those with possible sarcopenia,lower education level,central obesity and depression might be at high risk for frailty,and early interventions for high-risk population can be taken to slow the progression of frailty.

关 键 词：衰弱 可能肌少症 中老年人 

分 类 号：R47[医药卫生—护理学]