健康体检儿童幽门螺杆菌感染状况及影响因素分析  

Analysis of Helicobacter pylori(Hp)infection status and influencing factors in healthy children

作　　者：张艳芳 赵冬瑶 时晓鑫 Zhang Yanfang;Zhao Dongyao;Shi Xiaoxin(Health Management Center of Fuwai Central China Cardiovascular Hospital,Henan Key Laboratory of Chronic Disease Health Management,Zhengzhou451460,China)

机构地区：[1]阜外华中心血管病医院健康管理中心,河南省慢病健康管理重点实验室,郑州451460

出　　处：《中华健康管理学杂志》2025年第1期31-35,共5页Chinese Journal of Health Management

基　　金：河南省医学科技攻关计划省部共建重点项目(SBGJ202102048)。

摘　　要：目的分析健康体检儿童幽门螺杆菌(Hp)感染状况及影响因素。方法本研究为横断面研究。回顾性收集2022年12月至2023年12月在阜外华中心血管病医院健康管理中心行13C尿素呼气试验检查的684例3~14岁儿童资料,其中符合条件的652例纳入分析。根据是否感染Hp分为感染组和未感染组,比较两组年龄、性别、生活习惯等方面的差异。采用多因素logistic回归分析影响Hp感染的因素。结果652例儿童中,感染组134例,未感染组518例,Hp感染率20.6%。随着年龄增加,Hp感染率上升,3~5岁、6~11岁、12~14岁Hp感染率分别为12.6%、22.0%、25.2%(χ^(2)=9.862,P=0.007)。单因素分析显示:从不洗手、学校食堂就餐、不分餐、口嚼食物喂养、啃手指或玩具、同住亲属有胃肠道疾病史、家庭收入低、父母受教育程度低、婴儿期混合/人工喂养的儿童Hp感染比例较高,分别为26.1%、24.1%、25.4%、25.7%、26.0%、25.8%、25.1%、23.7%、23.6%(均P<0.05)。多因素分析显示:分餐、好的洗手习惯、家庭经济收入高是Hp感染的保护因素(OR=0.689、0.779、0.602,P=0.004、0.013、0.019),而口嚼食物喂养是Hp感染的危险因素(OR=1.998,P=0.001)。结论郑州市健康体检儿童Hp感染率处于中下水平,主要影响因素为分餐、洗手习惯、口嚼食物喂养、家庭收入。ObjectiveTo analyze the infection status and influencing factors of Helicobacter pylori(Hp)in healthy children.MethodsThis is a cross-sectional study.The data of 684 children aged 3 to 14 years who underwent the 13C urea breath test in the Health Management Center of Fuwai Central China Cardiovascular Hospital from December 2022 to December 2023 were retrospectively collected,and 652 of them who met the criteria were included in the analysis.According to whether they were infected with Hp,the children were divided into the infected group and the non-infected group,and the differences in age,gender,living habits and other aspects between the two groups were compared.Multivariate logistic regression analysis was used to analyze the factors influencing Hp infection.ResultsAmong the 652 children,there were 134 cases in the infected group and 518 cases in the non-infected group,with an Hp infection rate of 20.6%.The Hp infection rate showed an upward tendency with age.The Hp infection rates in children aged 3 to 5 years,6 to 11 years,and 12 to 14 years were 12.6%,22.0%,and 25.2%respectively(χ^(2)=9.862,P=0.007).Univariate analysis showed that the proportions of Hp infection were higher in children who never washed their hands,ate in school cafeterias,did not have separate meals,were fed with chewed food,bit their fingers or toys,lived with relatives who had a history of gastrointestinal diseases,had low family income,had parents with low educational level,and were mixed/artificially fed during infancy,which were 26.1%,24.1%,25.4%,25.7%,26.0%,25.8%,25.1%,23.7%,and 23.6%respectively(all P<0.05).Multivariate analysis showed that separate meals,good handwashing habits,and high family income were protective factors against Hp infection(OR=0.689,0.779,0.602,P=0.004,0.013,0.019),while feeding with chewed food was a risk factor for Hp infection(OR=1.998,P=0.001).ConclusionThe Hp infection rate of children undergoing health examination in Zhengzhou is at low level,and the main influencing factors are separate meals,handwashin

关 键 词：螺杆菌 幽门 儿童 感染 健康体检 影响因素 

分 类 号：R725.7[医药卫生—儿科]