脑电双频指数监测下环泊酚闭环靶控输注静脉麻醉在内镜下逆行胰胆管造影术中的运用  

Application of closed-loop target controlled infusion intravenous anesthesia of ciprofol under BIS monitoring in patients undergoing endoscopic retrograde cholangiopancreatography

作　　者：金运敏[1] 杨彦伟 刘骥[1] JIN Yun-min;YANG Yan-wei;LIU Ji(Department of Anesthesiology,Chuiyangliu Hospital,Beijing 100022,China)

机构地区：[1]北京市垂杨柳医院麻醉科,北京100022

出　　处：《中国中西医结合外科杂志》2025年第1期22-25,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:研究脑电双频指数(BIS)监测下环泊酚闭环靶控输注(CL-TCI)静脉麻醉用于内镜下逆行胰胆管造影术(ERCP)中的有效性和安全性。方法:回顾性选取2023年1月—2024年6月在我院择期行ERCP的60例患者,根据术中用药不同将患者分为两组:丙泊酚组(P组,n=30)和环泊酚组(C组,n=30)。记录麻醉诱导前(T_(0))、诱导成功后即刻(T_(1))、进入十二指肠乳头时(T_(2))、苏醒时(T_(3))的平均动脉压(MAP)、心率(HR)、脉搏血氧饱和度(SpO_(2))。记录麻醉诱导时间、苏醒时间、术中血管活性药物使用情况。记录术中注射痛、呼吸抑制、低血压、低心率、术后恶心呕吐等不良反应发生情况。结果:C组T_(1)、T_(2)点MAP、HR、SpO_(2)明显高于P组(P <0.05),两组T_(0)、T_(3)点的上述指标差异无统计学意义(P>0.05)。C组麻醉诱导时间长于P组,苏醒时间短于P组,血管活性药物使用率小于P组(P <0.05)。C组注射痛、呼吸抑制、低血压、低心率及术后恶心呕吐等不良反应发生率小于P组(P <0.05)。结论:BIS监测下环泊酚CL-TCI静脉麻醉用于ERCP的麻醉效果好,血流动力学稳定,苏醒快,不良反应发生率低,安全性好。Objective To investigate the efficacy and safety of application of closed-loop target controlled(CL-TCI) infusion intravenous anesthesia of ciprofol under BIS monitoring in patients undergoing endoscopic retrograde cholangiopancreatography(ERCP).Methods Sixty ASA Ⅱ-Ⅲ patients undergoing elective ERCP in our hospital from January 2023 to June 2024 were enrolled in this retrospective study.Patients were divided into two groups based on the use of different sedative drugs:the propofol group(group P,n=30) and the ciprofol group(group C,n =30).MAP,HR and SpO_(2) were recorded before induction of anesthesia(T_0),after induction of anesthesia(T_1),at time of reaching duodenal papilla(T_2),at time of withdrawing the endoscope(T_3).Induction time,awakening time,the application of vasoactive drugs,injection pain,respiratory depression,postoperative vomiting,hypotension and bradycardia were recorded.Results MAP,HR,SpO_(2at) T_(1and) T_(2in) group C was significantly higher than in group P(P <0.05),but had no significant difference at T_(0) and T_(3) in both groups(P >0.05).Induction time was longer and awakening time was shorter in group C than in group P.Application of vasoactive drugs,injection pain,respiratory depression,postoperative vomiting,hypotension,bradycardia in group C were less than in group P(P <0.05).Conclusion Both CL-TCI of ciprofol and propofol can achieve good sedation effects.Ciprofol provides more stable hemodynamic levels,shortens awakening time,and reduces the incidence of adverse events.Therefore,ciprofol CL-TCI intravenous anesthesia under BIS monitoring can be safely applicated in patients undergoing ERCP.

关 键 词：脑电双频指数 闭环靶控输注 环泊酚 内镜下逆行胰胆管造影术 

分 类 号：R971.2[医药卫生—药品]