中药穴位贴敷治疗良性前列腺增生症效果的Meta分析  

Meta-analysis of the effectiveness of traditional Chinese medicine acupoint application as an auxiliary treatment for benign prostatic hyperplasia

作　　者：徐君妍 刘瑞[3] 刘玉平 严佳胜 闵莎莎 王忠 王露 沈彦婷 XU Jun-yan;LIU Rui;LIU Yu-ping(School of Gongli Hospital Medical Technology,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学公利医院医疗技术学院,上海200093 [2]上海市浦东新区公利医院泌尿外科、男科学部,上海200135 [3]上海市浦东新区公利医院,上海200135 [4]上海市浦东新区公利医院营养科,上海200135

出　　处：《中国中西医结合外科杂志》2025年第1期81-87,共7页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金(62101319、82170788)。

摘　　要：目的:系统评价中药穴位贴敷治疗良性前列腺增生症(BPH)的临床疗效。方法:检索中国知网、万方、维普、Medline、Cochrane、Web of Science数据库,收集中药穴位贴敷治疗BPH的随机对照试验研究。采用RevMan 5.4对纳入文献进行质量评价、数据整合分析和敏感性分析,采用Stata 11.0进行发表偏倚评估。结果:最终纳入12项随机对照试验研究,共包含878例患者。Meta分析结果显示,中药穴位贴敷治疗组的国际前列腺评分表(I-PSS)评分显著低于对照组[MD=3.46,95%CI(2.19,4.74),P <0.001],而最大尿流率(Q_(max))显著高于对照组[MD=-2.72,95%CI(-3.76,-1.68),P <0.05],膀胱残余尿量少于对照组[MD=4.58,95%CI(4.05,5.12),P <0.05]。中药穴位贴敷治疗组相较于对照组的显效率[OR=2.14,95%CI(1.43,3.21),P=0.0002]及总有效率[OR=2.08,95%CI(1.24,3.49),P=0.005]均显著升高。结论:中药穴位贴敷治疗BPH的临床疗效良好。由于纳入的研究数量少且总体质量不高,因此仍需更多的高质量研究以增加论证强度。Objective To systematically evaluate the clinical efficacy of traditional Chinese medicine acupoint application in the treatment of benign prostatic hyperplasia(BPH).Methods Search the databases of CNKI,Wanfang,VIP,Medline,Cochrane,Web of Science to search for a randomized controlled trial of traditional Chinese medicine acupoint application for the treatment of BPH.Evaluate the methodological and reporting quality of qualified studies using the Cochrane risk bias tool and the comprehensive criteria for traditional Chinese medicine test reports,respectively.Perform Meta-analysis and evidence quality assessment using RevMan 5.4 software.Results 12 articles were ultimately selected,with a total of 878 cases.After the combination of traditional Chinese medicine acupoint application and conventional drug treatment,the International Prostate Scale(I-PSS) score was lower than that of conventional treatment [MD=3.46,95%CI(2.19,4.74),P <0.001],and Q_(max) was higher than that of conventional treatment [MD=-2.72,95%CI(-3.76,-1.68),P <0.05].The residual urine volume was lower than that of conventional treatment [MD=4.58,95%CI(4.05,5.12),P <0.05].The significant efficiency [OR=2.14,95%CI(1.43,3.21),P =0.0002] and the total effective rate [OR=2.08,95%CI(1.24,3.49),P =0.005] of the TCM acupoint application group were significantly higher than those of conventional group.Conclusion Traditional Chinese medicine acupoint application and its combination with Western medicine treatment can improve BPH related outcome indicators,and clinical application is safer.However,there is significant heterogeneity among the included studies,and in the future,clinical trials with larger sample sizes,rigorous design,and compliance with international standards are needed to provide more reliable evidence-based evidence for clinical practice.

关 键 词：中药穴位贴敷 良性前列腺增生症 系统评价 META分析 

分 类 号：R697.32[医药卫生—泌尿科学]