Development of NIR Responsive Upconversion Nanosensor for Turn-on Detection of 4-Nonylphenol  

近红外响应上转换荧光纳米传感器用于4-壬基苯酚检测

作　　者：HUANG Sili XU Kuncheng YE Yiwen WEN Hongli CHEN Rihui SONG Wei CHEN Wei ABDUR Raheem Aleem 黄丝丽;许坤城;叶依文;温红丽;陈日晖;宋巍;陈伟;ABDUR Raheem Aleem(广东工业大学轻工化工学院,广东省教育厅清洁化学技术重点实验室,广东省现代精细化工工程技术研究开发中心,广东广州510006;化学与精细化工广东省实验室揭阳分中心,广东揭阳515200;广东工业大学分析测试中心,广东广州510006;西安交通-利物浦大学芯片学院,江苏苏州215123;浙江理工大学生命科学与医药学院,重大疾病靶向治疗新技术和应用浙江省工程研究中心,浙江杭州310018)

机构地区：[1]Key Laboratory of Clean Chemistry Technology of Guangdong Regular Higher Education Institutions,Guangdong Engineering Technology Research Center of Modern Fine Chemical Engineering,School of Chemical Engineering and Light Industry,Guangdong University of Technology,Guangzhou 510006,China [2]Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center,Jieyang 515200,China [3]Analysis and Test Center,Guangdong University of Technology,Guangzhou 510006,China [4]School of CHIPS,Xi’an Jiaotong-Loverpool University,Suzhou 215123,China [5]Zhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases,College of Life Sciences and Medicine,Zhejiang Sci-Tech University,Hangzhou 310018,China

出　　处：《发光学报》2025年第1期140-155,共16页Chinese Journal of Luminescence

基　　金：国家自然科学基金(22075052);广东省基础与应用基础研究基金(2023A1515012988);广东省省级科技计划项目(2022A0505020005);江苏省教育厅项目(EFP10120240023)。

摘　　要：4-Nonylphenol(NP)is a kind of estrogen belonging to the endocrine disrupter,widely used in various agricultural and industrial goods.However,extensive use of NP with direct release to environment poses high risks to both human health and ecosystems.Herein,for the first time,we developed near-infrared(NIR)responsive upconversion luminescence nanosensor for NP detection.The Förster resonance energy transfer based upconversion nanoparticles(UCNPs)-graphene oxide sensor offers highly selective and sensitive detection of NP in linear ranges of 5−200 ng/mL and 200−1000 ng/mL under 980 nm and 808 nm excitation,respectively,with LOD at 4.2 ng/mL.The sensors were successfully tested for NP detection in real liquid milk samples with excellent recovery results.The rare-earth fluoride based upconversion luminescence nanosensor with NIR excitation wavelength,holds promise for sensing food,environmental,and biological samples due to their high sensitivity,specific recognition,low LOD,negligible autofluorescence,along with the deep penetration of NIR excitation sources.4-壬基苯酚(NP)是一种雌激素,属于内分泌干扰物,广泛应用于各种农业和工业品。然而,NP的过度使用及直接释放到环境中,会对人类健康和生态系统造成高风险。在此,我们首次研究了近红外(NIR)响应的上转换荧光纳米传感器用于4-NP的检测。基于Förster共振能量传递的上转换纳米颗粒(UCNPs)-氧化石墨烯传感器具有高选择性和高灵敏度,在980 nm和808 nm激发下,对NP的线性检测范围分别为5~200 ng/mL和200~1000 ng/mL,LOD为4.2 ng/mL。该纳米传感器在实际液体牛奶样品中成功进行了NP检测,结果令人满意。近红外激发的稀土氟化物基上转换荧光纳米传感器由于具有高灵敏度、高特异性识别、低LOD、无自发荧光以及近红外激发源的穿透能力强,在食品安全检测、环境监控和生物样品中具有很好的应用前景。

关 键 词：Er^(3+)/Yb^(3+)/Nd^(3+) upconversion nanoparticles Förster resonance energy transfer ESTROGEN DETECTION 

分 类 号：O482.31[理学—固体物理]