未接种季节性流感疫苗人群流感罹患率Meta分析  

A meta-analysis of the incidence of seasonal influenza among unvaccinated individuals

作　　者：胡昱[1] 龚杰 Hu Yu;Gong Jie(Institute of Immunization and Prevention,Zhejiang Provincial Center for Disease Control and Prevention,Hangzhou 310051,China;Medical Information and Health Policy Research Center,Hangzhou Medical College,Hangzhou 310013,China)

机构地区：[1]浙江省疾病预防控制中心免疫规划所,杭州310051 [2]杭州医学院卫生健康政策研究院,杭州310013

出　　处：《国际流行病学传染病学杂志》2024年第6期386-393,共8页International Journal of Epidemiology and Infectious Disease

摘　　要：目的评价未接种季节性流感疫苗人群的流感罹患率。方法检索美国国家医学图书馆数据库、考克兰Cochrane协作网图书馆、美国临床试验数据库等外文电子数据库、中国生物医学文献数据库、中国期刊全文数据库、万方全文数据库,将报告安慰剂组实验室确诊的流感罹患率的季节性流感疫苗随机对照研究纳入本次分析,合并计算未接种季节性流感疫苗人群中流感显性感染罹患率、流感显性和隐性感染合计罹患率。使用STATA 13.0进行Meta分析。结果共纳入32篇随机对照试验文献。仅估计显性感染,<18岁未接种季节性流感疫苗人群流感罹患率为14%,18~64岁未接种季节性流感疫苗人群流感罹患率为4%,≥65岁未接种季节性流感疫苗人群流感罹患率为7%;同时估计显性和隐性感染,<18岁未接种季节性流感疫苗人群流感罹患率为25%,18~64岁未接种季节性流感疫苗人群流感罹患率为11%。结论未接种季节性流感疫苗的人群中,流感发病率在不同年龄组之间差异有显著性意义,儿童和老年人群体的发病率较高。Objective To evaluate the incidence of seasonal influenza among unvaccinated individuals.Methods Foreign databases including the National Library of Medicine,Cochrane Library,and ClinicalTrials.gov,as well as Chinese databases such as the China Biomedical Literature Database,China Journal Full-text Database,and Wanfang Data were searched.Randomized controlled trials(RCTs)assessing the incidence of laboratory-confirmed influenza in placebo groups receiving seasonal influenza vaccines were included in the analysis.The study calculated the incidence rates of symptomatic influenza and the combined incidence rates of both symptomatic and asymptomatic influenza in unvaccinated populations.Meta-analysis was conducted using STATA 13.0.Results A total of 32 RCTs were included.The pooled incidence rates of symptomatic influenza were 14% for individuals<18 years,4% for individuals aged 18-64 years,and 7% for individuals≥65 years.The incidence rates of symptomatic and asymptomatic influenza were 25% for individuals<18 years,and 11% for individuals aged 18-64 years.Conclusions Among individuals not receiving the seasonal influenza vaccine,the incidence of influenza significantly differs across age groups,with higher incidence rates observed in children and the elderly.

关 键 词：流感 季节性 罹患率 未接种疫苗人群 META分析 随机对照试验 

分 类 号：R18[医药卫生—流行病学]