肉桂醛药理作用及相关作用机制研究进展  

Research progress in pharmacological effects and related mechanisms of cinnamaldehyde

作　　者：王清泉 李亚男 刘国飞 吴明泽 刘晓美 刘永俊 孙志强 代龙 WANG Qingquan;LI Yanan;LIU Guofei;WU Mingze;LIU Xiaomei;LIU Yongjun;SUN Zhiqiang;DAI Long(School of Pharmacy,Binzhou Medical University,Yantai 264003,China;College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong Yuze Institute of Pharmaceutical and Health Industry Technology,Dezhou 251200,China;Shandong Runzhong Pharmaceutical Co.,Ltd.,Yantai 264000,China)

机构地区：[1]滨州医学院药学院,烟台264003 [2]山东中医药大学药学院,济南250355 [3]山东禹泽药康产业技术研究院有限公司,德州251200 [4]山东润中药业有限公司,烟台264000

出　　处：《中华中医药杂志》2024年第12期6646-6652,共7页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：中央引导地方科技发展专项资金项目(No.YDZX2021050)。

摘　　要：肉桂醛是一种从肉桂等中药中分离出来的具有生物活性的植物化学物质,被认为具有广泛的医疗作用。文章在前期研究工作的基础上总结了近几年肉桂醛在神经损伤、骨骼损伤、抗癌、抑菌等方面的研究进展,并发现肉桂醛可通过作用于多种信号通路发挥这些作用。文章还针对亟需解决的问题提出了建议,以期为肉桂醛的临床安全使用和新药研发提供参考。Cinnamaldehyde is a bioactive phytochemical isolated from traditional Chinese medicine such as Cinnamomi Cortex,which is considered to have extensive medical effects.Based on previous research work,this article summarizes the research progress of cinnamaldehyde in recent years in the fields of nerve damage,bone damage,anticancer,antibacterial,and so on,and finds that cinnamaldehyde can exert these effects by acting on various signal pathways.This article also puts forward suggestions for the urgent problems to be solved,with a view to providing reference for the clinical safe use of cinnamaldehyde and the development of new drugs.

关 键 词：肉桂醛 药理活性 作用机制 安全性 食用性 进展 

分 类 号：R28[医药卫生—中药学]