基于“肺与大肠相表里”探讨肠道菌群和下呼吸道感染的因果关联:一项双样本孟德尔随机化研究  

Exploring on the causal link between gut microbiota and lower respiratory tract infections based on the‘tnterior-exterior relationship between the lung and large intestine’:A two-sample Mendelian randomization study

作　　者：何嘉伟 毛宁锋 赵毅 王淼 吕文亮[1,2] 周姝含 HE Jiawei;MAO Ningfeng;ZHAO Yi;WANG Miao;LYU Wenliang;ZHOU Shuhan(Institute of Epidemic Disease,Hubei University of Chinese Medicine,Wuhan 430061,China;College of Traditional Chinese Medicine,Hubei University of Chinese Medicine,Wuhan 430061,China)

机构地区：[1]湖北中医药大学疫病研究所,武汉430061 [2]湖北中医药大学中医学院,武汉430061

出　　处：《中华中医药杂志》2024年第12期6678-6683,共6页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家中医药管理局中医药创新团队及人才支持计划项目(No.ZYYCXTD-D-202203);湖北省自然科学基金项目(No.2023AFD138);湖北省科学技术厅重点研发计划项目(No.2020BCB015)。

摘　　要：目的:利用两样本孟德尔随机化(MR)方法探究211种肠道菌群与下呼吸道感染(LRTI)的因果关系。方法:通过两样本MR分析,以研究肠道菌群与5种LRTI疾病之间的关系,包括急性支气管炎、急性细支气管炎、支气管扩张、细菌性肺炎和流感肺炎。对于MR分析,主要采用逆方差加权(IVW)方法作为主要分析工具,并对其异质性和多效性进行验证。此外,采用了留一法来评估MR结果的稳定性。结果:有15种可能的微生物类群(具体为急性支气管炎3种、急性细支气管炎3种、支气管扩张3种、细菌性肺炎3种和流感肺炎3种)在LRTI的发生与发展过程中发挥潜在作用。结论:提示肠道菌群与LRTI之间存在因果关系,从而为肠道菌群介导的LRTI预防及治疗提供了新的见解。Objective:To investigate the causal link between 211 gut microbiota species and lower respiratory tract infections(LRTI)using a two-sample Mendelian randomization(MR)approach.Methods:A two-sample MR analysis was conducted to explore the relationship between gut microbiota and five types of LRTI,including acute bronchitis,acute bronchiolitis,bronchiectasis,bacterial pneumonia and influenza pneumonia.For MR analysis,the inverse variance weighted(IVW)method was used as the primary analytical tool,with heterogeneity and pleiotropy tested to ensure robustness.Additionally,leave-oneout analysis was performed to assess the stability of the MR results.Results:There were 15 microbial taxa potentially associated with LRTI,including three taxa related to acute bronchitis,three to acute bronchiolitis,three to bronchiectasis,three to bacterial pneumonia,and three to influenza pneumonia.Conclusion:This study provides evidence of a causal link between gut microbiota and LRTI,offering new insights into the prevention of LRTI mediated by gut microbiota.

关 键 词：下呼吸道感染 肠道菌群 孟德尔随机化 因果关系 肺与大肠相表里 

分 类 号：R56[医药卫生—呼吸系统]