针刺改善非痴呆型血管性认知障碍患者相关认知域:一项多中心随机对照研究的二次分析  

Secondary analysis of a multi-center randomized controlled trial on acupuncture for improving cognitive domains in patients with vascular cognitive impairment no dementia

作　　者：曹燕 赵吉平[1] 汪露 闫超群 杨静雯 石广霞 肖凌勇 刘存志[2] CAO Yan;ZHAO Jiping;WANG Lu;YAN Chaoqun;YANG Jingwen;SHI Guangxia;XIAO Lingyong;LIU Cunzhi(Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;School of Acupuncture-Moxibustion and Tuina,Beijing University of Chinese Medicine,Beijing 100029,China;Acupuncture and Moxibustion Department,First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300380,China;National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300380,China)

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学针灸推拿学院,北京100029 [3]天津中医药大学第一附属医院针灸部,天津300380 [4]国家中医针灸临床医学研究中心,天津300380

出　　处：《中华中医药杂志》2024年第12期6878-6881,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：北京市科技计划课题“首都临床特色应用研究”专项(No.Z131107002213034);国家重点研发计划重点专项(No.2022YFC 3500500)。

摘　　要：目的:评价针刺改善非痴呆型血管性认知障碍(VCIND)患者不同认知域的临床疗效。方法:216例VCIND患者以1∶1的比例随机分配至针刺组和药物组,对患者治疗前、12周治疗后和24周随访时阿尔茨海默病评估量表的记忆、执行、语言和注意力4个认知域进行分析;按照受教育年限分为高等教育组和非高等教育组,评估教育对4个认知域评分的影响。结果:与药物组比较,针刺组治疗后记忆和注意力评分显著改善(P<0.05),随访时执行评分显著改善(P<0.05)。接受高等教育组中针刺组治疗后注意力评分显著优于药物组(P<0.01);非高等教育组中针刺组治疗后和随访时执行评分均显著优于药物组(P<0.05)。结论:针刺能够显著改善患者记忆、注意力和执行功能。在接受高等教育的人群中,针刺对注意力的改善效果更好,而在未接受高等教育的人群中,针刺对执行功能的改善效果更好。Objective:To evaluate the clinical efficacy of acupuncture in improving different cognitive domains in patients with vascular cognitive impairment no dementia(VCIND).Methods:A total of 216 VCIND patients were randomly assigned to an acupuncture group and a medication group in a 1:1 ratio.The four cognitive domains of memory,executive function,language,and attention were analyzed using the Alzheimer’s Disease Assessment Scale before treatment,at 12 weeks post-treatment,and during the 24-week follow-up.Based on years of education,patients were further divided into a higher education group and a non-higher education group to assess the influence of education on these four cognitive domains.Results:Compared to the medication group,the acupuncture group demonstrated significant improvements in memory and attention sco post-treatment(P<0.05),and significant improvements in executive function scores during follow-up(P<0.05).In the higher education group,attention scores were superior in the acupuncture group compared to the medication group(P<0.01).In the nonhigher education group,executive function scores were better in the acupuncture group both post-treatment and during followup than that in medication group(P<0.05).Conclusion:Acupuncture significantly improves memory,attention,and executive function among patients.Among those with higher education,acupuncture shows a more pronounced effect on improving attention,while among those with non-higher education,acupuncture exhibits a superior effect on enhancing executive function.

关 键 词：针刺 非痴呆型血管性认知障碍 认知域 执行 记忆 语言 注意力 教育 

分 类 号：R24[医药卫生—中医临床基础]