不同激发波长下对6种毒品缴获物的拉曼光谱检验研究  

Raman Spectroscopic Examination of Six Drug Seizures at Different Excitation Wavelengths

作　　者：马甜 MA Tian(National Anti-Drug Laboratory Shaanxi Regional Center,Xi’an 710016,China)

机构地区：[1]国家毒品实验室陕西分中心,西安710016

出　　处：《刑事技术》2025年第1期33-40,共8页Forensic Science and Technology

摘　　要：本文基于拉曼光谱法,比较了6种毒品缴获物分别在三种不同的激发波长(532、785、1064 nm)下的拉曼光谱检验表现。对照毒品标准物质的拉曼谱图,在拉曼指纹区(100~1800 cm^(-1))内选取3~5个散射强度较高且不受常见掺杂物干扰的特征散射峰作为毒品缴获物的定性匹配依据。结果发现,毒品缴获物的拉曼检验需要根据毒品种类选择适合的激发波长,对于有掺杂物质的毒品缴获物,应选择避开掺杂的毒品特征峰进行拉曼比对。对于缴获的海洛因(HER)、咖啡因(CAF)及3,4亚甲基二氧基甲基苯丙胺(MDMA),785和1064 nm的近红外(NIR)激发波长相较于532 nm的拉曼检验表现更优,其中1064 nm能显著降低HER缴获物的背景荧光;对于缴获的甲基苯丙胺(MAMP)及氯胺酮(KET),受激发波长改变的影响较小,三种不同激发波长下拉曼均响应良好,指纹区与官能团区(2500~3200 cm^(-1))拉曼谱峰的相对强度呈现规律性变化;对于麻古(Magu)的拉曼分析,785 nm激发波长更优、空间分辨率更高,避免荧光效应的同时能够观察到更多特征峰信息。该研究工作基于拉曼光谱法,能为缉毒执法工作提供有力的参考。In this article,the Raman spectrum inspection performance of six drug seizures at three different excitation wavelengths(532,785,and 1064 nm)is compared using Raman spectroscopy.Three tofive distinctive scattering peaks in the Ramanfingerprint area(100–1800 cm^(-1)),with greater scattering intensity and no interference from typical adulterants,were chosen as the bass for the qualitative matching of the drug seizures when compared to the Raman spectra of the drug standards.It was discovered that in order to perform a Raman investigation of drug seizures,appropriate excitation wavelengths must be chosen based on the kind of drug involved.Additionally,if the drug seizures contain adulterated substances,the distinctive peaks of the pharmaceuticals that escape adulteration should be chosen for comparison.For seized heroin(HER),caffeine(CAF)and 3,4-methylenedioxymethamphetamine(MDMA),the near-infrared(NIR)excitation wavelengths of 785 nm and 1064 nm are better than that of 532 nm for the Raman test,in which the 1064 nm significantly reduces the backgroundfluorescence of the HER seizure;for seized methamphetamine(MAMP)and ketamine(KET),the effect of the change of excitation wavelength was small,and the Raman response was good at three different excitation wavelengths,and the relative intensities of the Raman peaks in thefingerprint region and the functional group region(2500 to 3200 cm^(-1))showed regular changes;for the Raman analysis of Magu,the excitation wavelength of 785 nm was superior,with a higher spatial resolution,which could observe more characteristic peak information while avoiding the fluorescence effect.This research work is based on Raman spectroscopy,which will provide a strong reference and basis for drug enforcement.

关 键 词：激发波长 拉曼光谱 荧光 毒品缴获物 掺杂物 

分 类 号：DF795.1[医药卫生—法医学]