生物组织光子传输蒙特卡罗仿真加速技术研究综述  

Comprehensive Review of Acceleration Techniques for Monte Carlo Simulations of Photon Transport in Biological Tissues

作　　者：徐楼喆 李婷 Xu Louzhe;Li Ting(Institute of Biomedical Engineering,Chinese Academy of Medical Sciences,Tianjin 300192,China)

机构地区：[1]中国医学科学院生物医学工程研究所,天津300192

出　　处：《中国激光》2024年第21期50-61,共12页Chinese Journal of Lasers

基　　金：中国医学科学院健康创新工程系列项目(2021-I2M-1-042,2021-I2M-1-058,2022-I2M-C&T-B-012)。

摘　　要：生物组织光子传输蒙特卡罗模拟方法对指定光学参数的组织模型进行随机抽样计算,理论上,对于任意复杂模型都可以达到非常高的计算精度。在实际使用时,蒙特卡罗模拟方法计算时间长的特点限制了其精度的提高,因此本文重点关注蒙特卡罗模拟加速方法和技术的进展,分析了各种加速方法的原理,比较了加速方法的速度、精度和适用场景,讨论了未来蒙特卡罗方法在组织光学领域发展的潜在方向。Significance In the dynamic field of biomedical photonics,simulating light transport in biological tissues has become a cornerstone for advancing medical diagnostics,therapeutic interventions,and understanding photobiological processes.This research area is crucial due to its potential to transform a wide range of biomedical applications.These include high-resolution medical imaging technologies,such as optical coherence tomography and fluorescence imaging,and innovative therapeutic approaches such as photodynamic therapy.These simulations provide detailed insights into the complex interactions between light and biological tissues,enhancing the precision of medical diagnostics,allowing for tailored light-based treatments for individual patients,and furthering our understanding of light-induced biological effects.Monte Carlo(MC)simulation methods are at the forefront of this field,noted for their unparalleled flexibility and accuracy in modeling the stochastic nature of photon transport through media with diverse optical properties.The MC approach excels at replicating the complex phenomena of absorption,scattering,reflection,and refraction that characterize light’s interaction with heterogeneous biological tissues.Its ability to theoretically achieve any desired level of precision establishes it as the gold standard for simulating complex tissue optics scenarios,providing a crucial benchmark for validating results from other modeling techniques.However,the practical use of MC simulations is significantly hindered by their high computational demands,which require extended periods to produce accurate results.This limitation not only affects the method’s efficiency but also presents a major barrier to its application in real-time or high-throughput settings.Consequently,there is a pressing need for innovative acceleration techniques that can reduce the computational load of MC simulations without sacrificing accuracy.Developing and implementing such strategies is essential to broaden the use and impact of photon

关 键 词：医用光学 光子传输 仿真 蒙特卡罗模拟 加速 

分 类 号：O436[机械工程—光学工程]