磁感应热疗系统研发进展  

Development of Magnetic⁃Induction Hyperthermia System

作　　者：张建锋 焦王博 樊海明 刘晓丽[3,4] Zhang Jianfeng;Jiao Wangbo;Fan Haiming;Liu Xiaoli(School of Physics,Northwest University,Xi’an 710127,Shaanxi,China;Center for Nanomedicine and Engineering,College of Chemistry and Materials Science,Northwest University,Xi’an 710127,Shaanxi,China;National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine,Shaanxi Province Center for Regenerative Medicine and Surgery Engineering Research,Shaanxi Provincial Key Laboratory of Magnetic Medicine,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,Shaanxi China;Institute of Regenerative and Reconstructive Medicine,Med-X Institute,First Affiliated Hospital of Xi’an Jiaotong University,Xi’an 710061,Shaanxi,China)

机构地区：[1]西北大学物理学院,陕西西安710127 [2]西北大学化学与材料科学学院,纳米医学与工程研究中心,陕西西安710127 [3]西安交通大学第一附属医院精准外科与再生医学国家地方联合工程研究中心,陕西省再生医学与外科工程研究中心,陕西省磁性医学重点实验室,陕西西安710061 [4]西安交通大学第一附属医院,Med-X研究院,再生与重建医学研究所,陕西西安710061

出　　处：《中国激光》2024年第21期152-163,共12页Chinese Journal of Lasers

基　　金：国家自然科学基金优秀青年科学基金项目(82322039);国家重点研发计划青年科学家项目(2022YFC2408000);国家自然科学基金项目(82072063);陕西省重点研发计划项目(2023-YBSF-132);西安交通大学第一附属医院医工交叉项目(QYJC02);南京正大天晴科研基金项目(TQ202215)。

摘　　要：磁感应热疗(简称“磁热疗”)是一种新型的临床肿瘤物理疗法,该方法利用磁性纳米材料在交变磁场下产热并引发一系列分子事件来高效地杀伤肿瘤细胞。相较于传统的肿瘤治疗手段,如化疗和放疗,磁热疗具有创伤小、远程可控、可多次治疗、激发抗肿瘤免疫等优势,并已在临床肿瘤治疗中展现出了巨大的应用潜力。为了进一步提升这项技术的效果和适用性,在过去的几十年中,交变磁场发生器不断地优化和升级。本文重点介绍了基于逆变技术和功率放大技术设计的交变磁场发生器,详细阐述了它们的工作原理、线圈类型以及提高磁场特征参数(如频率、场强和均匀性)的改进和优化措施。同时,本文还简要介绍了两种具有磁场聚焦和波形变换功能的磁热疗系统。本文还探讨了将激光共聚焦显微镜和光谱仪分别与磁热疗设备相结合构建的科研平台,这种平台为在分子或细胞层面深入研究磁热效应提供了新的工具。最后,本文回顾了已报道的临床磁热疗设备,并对未来临床应用中磁热疗设备的发展方向进行了展望。随着技术的不断进步和优化,磁热疗将在未来的癌症治疗中扮演着越来越重要的角色,推动肿瘤物理治疗的疗效改善与预后提升。Significance Magnetic-induction hyperthermia,also known as magnetic hyperthermia,is an emerging physical-therapy modality for treating tumors clinically.It utilizes magnetic nanomaterials to generate heat under an alternating magnetic field(AMF),thereby triggering molecular events that selectively destroy tumor cells.Magnetic hyperthermia offers several advantages over conventional treatments such as chemotherapy and radiotherapy,including its minimal invasiveness,remote controllability,potential for repeatable treatments,and ability to induce anti-tumor immunity.These characteristics highlight the significant potential of magnetic hyperthermia in clinical tumor treatment.Over the recent decades,continuous effort has been expended to enhance the design of AMF generators,with emphasis on the integration of inverter and power-amplification technologies.However,comprehensive summaries regarding the development of AMF generators are insufficient.Therefore,an overview of currently used AMF generators is necessary to encourage the development of magnetic-hyperthermia devices for clinical applications.Progress This paper elucidates the operating principles,coil types,and strategies for optimizing the AMF characteristic parameters—such as frequency,field strength,and uniformity—of magnetic-hyperthermia generators.We review relevant magnetichyperthermia devices and summarize their advantages and disadvantages.AMF generators generate two types of magnetic fields,i.e.,coil and core types.The coil type uses various conductor configurations,such as spiral tubes,flat coils,and Helmholtz coils.By contrast,the core type involves a conductor wrapped around a magnetically conductive medium,such as ferrite,which transfers magnetic field energy and creates an AMF concentrated in the ferrite gap.Additionally,we introduce two magnetic-hyperthermia systems equipped with AMF focusing and waveform-transformation capabilities.Previous studies utilized three hollow spiral tubes as output terminals to construct a magnetic-hyperthermia s

关 键 词：交变磁场发生器 励磁线圈 磁场聚焦 磁场波形 临床抗肿瘤应用 

分 类 号：R318.6[医药卫生—生物医学工程]