中老年原发性高血压患者血清甲状旁腺素、25-羟维生素D水平与左心室肥厚的相关性  

Correlation between serum parathyroid hormone,25-hydroxyvitamin D levels and left ventricular hypertrophy in middle-aged and elderly patients with essential hypertension

作　　者：易春秀 赵雅静 张雯 张彩艳 郭子宏 YI Chunxiu;ZHAO Yajing;ZHANG Wen;ZHANG Caiyan;GUO Zihong(Cardiovascular Department,Fuwai Yunnan Hospital,Chinese Academyo f Medical Sciences,Kunming,Yunnan 650032,China)

机构地区：[1]云南省阜外心血管病医院心血管内科,云南昆明650032

出　　处：《中华高血压杂志(中英文)》2024年第12期1149-1155,共7页Chinese Journal of Hypertension

基　　金：2021年云南省科技厅昆明医科大学应用基础研究联合专项资金面上项目(202101AY070001-221,202101AY070001-222);云南省教育厅科学研究基金项目(2024J0329);云南高原心血管病流行特征、发病机制、诊疗新技术研究及应用示范项目(202103AC100004)。

摘　　要：目的探讨中老年原发性高血压患者血清甲状旁腺素(PTH)、25-羟维生素D[25(OH)D]水平与左心室肥厚(LVH)指标的相关性。方法随机收集2022年11月至2023年5月在云南省阜外心血管病医院心内科高血压病区住院的中老年原发性高血压患者204例,根据是否发生LVH分为LVH组(45例)、非LVH组(159例);采集患者的人口学资料、血红蛋白、尿酸、肌酐、血清钙离子、血清磷离子、动态血压及PTH、25(OH)D等指标。采用Pearson相关性分析方法分析原发性高血压患者PTH、25(OH)D与LVH的相关性;采用多元逐步线性回归分析方法分析原发性高血压患者血清PTH、25(OH)D对LVH的影响。结果LVH组PTH高于非LVH组[(56.19±27.16)比(49.01±18.78)ng/L,t=-2.036,P=0.043],25(OH)D低于非LVH组[(46.95±15.80)比(53.35±17.18)nmol/L,t=2.239,P=0.026]。Pearson相关性分析显示,PTH与室间隔厚度(IVST)、左心室质量指数(LVMI)呈正相关(r=0.203,P=0.004;r=0.170,P=0.015)。多元逐步线性回归分析显示,PTH是LVMI的影响因素(β=0.169,P=0.016)。结论原发性高血压患者PTH与LVMI呈正相关,PTH是LVH的影响因素。Objective To investigate the correlation between serum levels of parathyroid hormone(PTH),25-hydroxyvitamin D[25(OH)D]and left ventricular hypertrophy(LVH)in middle-aged and elderly patients with essential hypertension.Methods A total of 204 middle-aged and elderly patients with essential hypertension were randomly collected from the Hypertension Ward of the Cardiovascular Department,Fuwai Yunnan Hospital,Chinese Academy of Medical Sciences between November 2022 and May 2023.The patients were divided into LVH group(45 cases)and non-LVH group(159 cases).Demographic information,hemoglobin,uric acid,creatinine,serum calcium ions,serum phosphorus ions,ambulatory blood pressure monitoring and PTH,25(OH)D were collected.Pearson correlation analysis was used to analyze the correlation between PTH,25(OH)D and LVH in essential hypertension patients.Multivariate stepwise linear regression analysis was used to analyze the effect of serum PTH,25(OH)D on LVH in essential hypertensive patients.Results Compared with non-LVH group,PTH was higher[(56.19±27.16)vs(49.01±18.78)ng/L,t=-2.036,P=0.043],while 25(OH)D was lower[(46.95±15.80)vs(53.35±17.18)nmol/L,t=2.239,P=0.026]in the LVH group.Pearson correlation analysis showed that PTH was positively correlated with interventricular septal thickness(IVST)and left ventricular mass index(LVMI)(r=0.203,P=0.004;r=0.170,P=0.015).Multiple stepwise linear regression analysis showed that PTH(β=0.169,P=0.016)was an influence factor of LVMI.Conclusion PTH is positively associated with LVMI in essential hypertensive patients,and PTH is an influencing factor of LVH.

关 键 词：原发性高血压 甲状旁腺素 25-羟维生素D 左心室肥厚 

分 类 号：R544.11[医药卫生—心血管疾病]