HIF-1α在新生儿缺血缺氧性脑损伤中的作用  

The role of HIF-1αin neonatal hypoxic ischemic brain damage

作　　者：兰平 尚文豆 何治[1,2,3] 陈越 LAN Ping;SHANG Wen-Dou;HE Zhi;CHEN Yue(Third-grade Pharmacological Laboratory on Traditional Chinese Medicine,State Administration of Traditional Chinese Medicine,China Three Gorges University,Yichang 443002,China;Basic Medical College,China Three Gorges University,Yichang 443002,China;Jiaxing University Medical College,Jiaxing 314000,China)

机构地区：[1]三峡大学国家中药管理局中药药理科研三级实验室,宜昌443002 [2]三峡大学基础医学院,宜昌443002 [3]嘉兴大学医学院,嘉兴314000

出　　处：《生命科学》2024年第12期1525-1534,共10页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金面上项目(82073824);湖北省自然科学基金青年项目(2021CFB232)。

摘　　要：新生儿缺血缺氧性脑损伤(neonatal hypoxic ischemic brain damage,HIBD)是指围产期因多种不利因素导致新生儿大脑部分或完全缺血缺氧而引起的脑损伤疾病,其致死率和致残率高,发病机制复杂。缺氧诱导因子-1α(hypoxia-inducible factor-1α,HIF-1α)是调节细胞适应缺氧环境的关键转录因子。在HIBD中,HIF-1α的表达对神经元既有保护作用也有毒性作用,主要与新生儿大脑缺血缺氧的时间和程度有关。本文就HIF-1α及其所调控的下游基因在HIBD中的具体作用机制进行综述。Neonatal hypoxic ischemic brain damage(HIBD)is the major cause of mortality and morbidity to the newborn in the perinatal period,which results from partially or completely ischemia and hypoxia to the brain of neonates and leads to brain injury.HIBD is highly lethal and disabling,and its pathogenesis is complicated and not completely clear.Hypoxia-inducible factor-1α(HIF-1α)is a key transcription factor regulating cellular adaptation to hypoxic environments.In HIBD,HIF-1αhas both neuroprotective and neurotoxic effects,mainly related to the duration and degree of neonatal cerebral ischemia and hypoxia.The research evidence of HIF-1αin HIBD and downstream events,as well as the specific mechanisms are summarized and discussed in this review.

关 键 词：缺氧诱导因子-1Α 新生儿 缺血缺氧性脑损伤 

分 类 号：R722[医药卫生—儿科]