环形RNA数据库汇总及其应用  

circRNA databases and the application

作　　者：许钊源 王豫琪 何璐云 XU Zhao-Yuan;WANG Yu-Qi;HE Lu-Yun(First Clinical Medical College,Zhengzhou University,Zhengzhou 450001,China;Department of Pathophysiology,School of Basic Medical Sciences,Zhengzhou University,Zhengzhou 450001,China)

机构地区：[1]郑州大学第一临床医学院,郑州450001 [2]郑州大学基础医学院病理生理学系,郑州450001

出　　处：《生命科学》2024年第12期1562-1571,共10页Chinese Bulletin of Life Sciences

基　　金：河南省高等学校重点科研项目(23A310028)。

摘　　要：环形RNA(circular RNA,circRNA)是通过反向剪接形成的闭合非编码RNA分子。它可以通过多种方式参与细胞生命活动,同时也是肿瘤等多种疾病的生物标志物和潜在治疗靶点。随着高通量测序技术的发展和circRNA研究的不断深入,circRNA信息和功能注释不断增加。许多聚焦不同方向的circRNA数据库被建立,为circRNA研究者了解、分析、注释及研究circRNA提供了很大便利。本文收集了28个circRNA数据库并对其进行分类汇总,希望为研究者选择circRNA数据库提供一些参考和帮助。circular RNAs(circRNAs)are closed non-coding RNA molecules formed by back-splicing.circRNAs can involve in cell life by a variety of ways,and they are also biomarkers and potential therapeutic targets for a variety of diseases including cancers.With the development of high-throughput sequencing technology and the deepening research,the information and functional annotations of circRNAs become more and more.A number of circRNA databases focusing on different contents have been established,providing great convenience for circRNA researchers to understand,analyze,annotate and study circRNAs.In this paper,28 established circRNA databases are collected and classified,in order to provide references when selecting circRNA databases.

关 键 词：环形RNA 环形RNA数据库 信息汇总 生物标志物 

分 类 号：Q522[生物学—生物化学]