可吸入纳米颗粒研究进展  

Research Progress of Inhalable Nanoparticles

作　　者：周静 张靖彬 李洁 陈欢 付亚宁 厉昌坤[1] 侯宏卫 ZHOU Jing;ZHANG Jingbin;LI Jie;CHEN Huan;FU Yaning;LI Changkun;HOU Hongwei(Technology Center of China Tobacco Shandong Industry Co.,Ltd.,Jinan 250014,China;Beijing Life Science Academy,Bejing 102200,China)

机构地区：[1]山东中烟工业有限责任公司技术中心,济南250014 [2]北京生命科技研究院,北京102200

出　　处：《中国生物工程杂志》2024年第12期112-123,共12页China Biotechnology

摘　　要：吸入给药作为疾病治疗的一种新兴途径,与口服和静脉给药途径相比具有独特优势。然而,递送效果受到多种生理障碍的影响。因此,研究重点放在了优化载体的开发上,可吸入纳米颗粒在递送过程中展现出优异的设计优势和功能整合能力。概述了吸入给药设备与吸入制剂种类,进一步讨论了吸入给药面临的挑战,重点介绍近5年基于各种纳米颗粒的吸入给药策略,并对吸入给药纳米平台的发展前景进行展望,以期为吸入给药领域进一步研究和创新提供参考。Inhalation drug delivery is an emerging approach to disease treatment that offers unique advantages over oral and intravenous routes.However,there are several physiological barriers that affect delivery efficacy.Therefore,research has focused on optimizing carrier design,with inhalable nanoparticles demonstrating excellent design advantages and functional integration capabilities during the delivery process.In this review,we outline inhalation drug delivery devices and formulations and discuss the challenges of inhalation delivery.In particular,we highlight inhalation delivery strategies based on various nanoparticles over the past five years and provide perspectives on the development of inhalation drug delivery nano-platforms,with the aim of providing insights for further research and innovation in the field of inhalation drug delivery.

关 键 词：吸入给药 纳米颗粒 肺部疾病 

分 类 号：Q819[生物学—生物工程]