关注侵袭性A族链球菌疾病疫情  

Focus on the outbreaks of invasive group A streptococcal disease

作　　者：姚开虎 郭孟杨 Yao Kaihu;Guo Mengyang(Key Laboratory of Major Diseases in Children,Ministry of Education,National Clinical Research Center for Respiratory Diseases,National Key Discipline of Pediatrics,Laboratory of Infection and Microbiology,Beijing Pediatric Research Institute,Beijing Children′s Hospital,Capital Medical University,National Center for Children′s Health,Beijing100045,China)

机构地区：[1]国家儿童医学中心,首都医科大学附属北京儿童医院,北京市儿科研究所感染与微生物研究室,国家呼吸系统疾病临床医学研究中心,儿科学国家重点学科,儿科重大疾病研究教育部重点实验室,北京100045

出　　处：《中华医学杂志》2025年第2期117-122,共6页National Medical Journal of China

基　　金：兵团财政科技计划项目南疆重点产业创新发展支撑计划(2021DB020)。

摘　　要：近二三十年,尤其自2022年欧洲多国暴发猩红热和侵袭性A族链球菌疾病/感染(iGAS)疫情以来,iGAS引起了广泛关注。近期日本暴发了iGAS特殊类型——链球菌中毒性休克综合征(STSS)疫情,当局以"食人菌"的名称报道疫情,突显了GAS的致病威力。GAS并非新发病原,且有敏感抗菌药物,各种iGAS临床类型的诊断和治疗也有规范可循。但是,我国对iGAS缺乏系统监测和研究。日本STSS疫情及其较高的致死率警示我们仍需重视GAS疾病,关注iGAS流行病学新变化,以及菌株致病性和传播能力等改变,结合国内临床实践积极开展相关研究,提高iGAS临床诊治和防控水平,保障人民健康。In recent years,particularly since the outbreaks of scarlet fever and invasive group A streptococcal diseases/infections(iGAS)in several European countries in 2022,iGAS has garnered widespread attention.Recently,Japan experienced an outbreak of a specific type of iGAS,streptococcal toxic shock syndrome(STSS).The outbreak was reported under the label"flesh-eating bacteria,"emphasizing the pathogenic potential of group A streptococcus(GAS).Although GAS is not a newly emerging pathogen and remains susceptible to antibiotics,and guidelines exist for the diagnosis and treatment of various clinical manifestations of iGAS,systematic surveillance and research on iGAS are lacking in China.The high mortality rate associated with the STSS outbreak in Japan highlights the need for continued attention to GAS-related diseases,with a focus on emerging trends in iGAS epidemiology,as well as changes in bacterial virulence and transmission dynamics.There is a pressing need to conduct research based on domestic clinical practice to enhance iGAS diagnosis,treatment,and prevention,ultimately to safeguard public health.

关 键 词：A族链球菌 化脓性链球菌 侵袭性疾病 链球菌中毒性休克综合征 

分 类 号：R515[医药卫生—内科学] R181.8[医药卫生—临床医学]