Ammonium Sensing Patch with Ultrawide Linear Range and Eliminated Interference for Universal Body Fluids Analysis  

作　　者：Mingli Huang Xiaohao Ma Zongze Wu Jirong Li Yuqing Shi Teng Yang Jiarun Xu Shuhan Wang Kongpeng Lv Yuanjing Lin 

机构地区：[1]School of Microelectronics,Southern University of Science and Technology,Shenzhen 518055,People’s Republic of China [2]Department of Interventional Radiology,Shenzhen People’s Hospital,Shenzhen 518020,People’s Republic of China [3]College of Mechanical and Energy Engineering,Shaoyang University,Shaoyang 422000,Hunan,People’s Republic of China [4]Shenzhen Hainwise Medical Technology Co.,LTD,Shenzhen 518118,People’s Republic of China [5]Shenzhen Institute for Drug Control(Shenzhen Testing Center of Medical Devices),Shenzhen 518000,People’s Republic of China [6]Institute of Innovative Materials,Guangming Advanced Research Institute,Southern University of Science and Technology,Shenzhen 518055,People’s Republic of China

出　　处：《Nano-Micro Letters》2025年第4期332-346,共15页纳微快报(英文版)

基　　金：supported by the National Natural Science Foundation of China(62201243);Natural Science Foundation of Guangdong Province(2022A1515011928);Shenzhen Science and Technology Program(Grant No.RCYX20231211090432060,JSGGZD20220822095600001);Postgraduate Scientific Research Innovation Project of Hunan Province(CX20231306);the technical support from the Southern University of Science and Technology Core Research Facilities(SUSTech CRF)。

摘　　要：Ammonium level in body fluids serves as one of the critical biomarkers for healthcare,especially those relative to liver diseases.The continuous and real-time monitoring in both invasive and noninvasive manners is highly desired,while the ammonium concentrations vary largely in different body fluids.Besides,the sensing reliability based on ion-selective biosensors can be significantly interfered by potassium ions.To tackle these challenges,a flexible and biocompatible sensing patch for wireless ammonium level sensing was reported with an ultrawide linear range for universal body fluids including blood,tears,saliva,sweat and urine.The as-prepared biocompatible sensors deliver a reliable sensitivity of 58.7 mV decade-1 in the range of 1-100 mM and a desirable selectivity coefficient of 0.11 in the interference of potassium ions,attributed to the cross-calibration within the sensors array.The sensor’s biocompatibility was validated by the cell growth on the sensor surface(>80%),hemolysis rates(<5%),negligible cellular inflammatory responses and weight changes of the mice with implanted sensors.Such biocompatible sensors with ultrawide linear range and desirable selectivity open up new possibility of highly compatible biomarker analysis via different body fluids in versatile approaches.

关 键 词：Biocompatible sensors Implantable bioelectronics Ammonium sensing CROSS-CALIBRATION Ultrawide linear range 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]