吲哚类生物碱的抗肿瘤作用机制研究进展  

Research Progress on the Anti-tumor Mechanism of Indole Alkaloids

作　　者：权慧艳 陈玉琳 商洪玉 金玉雪 何述钟 杨岚 QUAN Hui-yan;CHEN Yu-lin;SHANG Hong-yu;JIN Yu-xue;HE Shu-zhong;YANG Lan(College of Pharmacy,Guizhou University,Guiyang 550025,China;Guizhou Provincial Engineering Laboratory for Synthetic Drugs,Guiyang 550025,China)

机构地区：[1]贵州大学药学院,贵州贵阳550025 [2]贵州省合成药物工程实验室,贵州贵阳550025

出　　处：《化学试剂》2025年第2期1-7,共7页Chemical Reagents

基　　金：贵州大学基础研究项目(贵大基础[2023]49号);贵州大学大学生创新创业训练计划项目(gzugc2024045);贵州大学2024年实验室开放项目(SYSKF2024-011)。

摘　　要：吲哚类生物碱是一类重要的杂环生物碱,因来源广、结构多样、药理作用广泛而成为抗肿瘤药物研究热点,其抗肿瘤机制涵盖诱导凋亡、抑制侵袭、调控细胞周期与miRNA、促进自噬及增强免疫等多个方面,在肿瘤治疗领域具有巨大的开发潜力。结合文献,针对吲哚类生物碱的抗肿瘤作用机制进行综述,以期为进一步研究和应用提供参考。As an important class of heterocyclic alkaloids,indole alkaloids have become a research hotspot in anti-tumor drugs,because of their wide sources,diverse structures,and broad pharmacological effects.The anti-tumor mechanisms of indole alkaloids encompass multiple aspects,such as inducing apoptosis,inhibiting invasion,regulating cell cycle and miRNA,promoting autophagy,and enhancing immunity,which shows great potential for development in the field of tumor treatment.The anti-tumor mechanisms of indole alkaloids based on existing literature were summarized.It aimed to provide reference for further research and application.

关 键 词：吲哚类生物碱 抗肿瘤 作用机制 研究进展 信号通路 

分 类 号：O626.24[理学—有机化学]