血清总25-羟维生素D、雌二醇联合膀胱尿道后角在女性SUI中的诊断价值分析  

Serum total 25-hydroxyvitamin D and estradiol in combination with the posterior vesicourethral angle in the diagnosis of women with stress urinary incontinence

作　　者：龚蔚 潘铁军 刘波 赵夫汉 许亚龙 田洪哲 GONG Wei;PAN Tiejun;LIU Bo;ZHAO Fuhan;XU Yalong;TIAN Hongzhe(Graduate Student Joint Training Base of General Hospital of Central Theater Command of Wuhan Universityof Science and Technology,Wuhan,430070,China;Medical College,Wuhan University of Science and Technology;Department of Urology,General Hospital of Central Theater Command)

机构地区：[1]武汉科技大学中部战区总医院研究生培养基地,武汉430070 [2]武汉科技大学医学部医学院 [3]中部战区总医院泌尿外科

出　　处：《临床泌尿外科杂志》2024年第12期1091-1094,共4页Journal of Clinical Urology

摘　　要：目的:探讨血清总25-羟维生素D、血清雌二醇、膀胱尿道后角诊断女性压力性尿失禁(stress urinary incontinence,SUI)的临床价值。方法:选择2024年6月—9月于中部战区总医院泌尿外科就诊的30例女性SUI患者作为病例组,同期无SUI的健康体检女性30例作为对照组。比较分析2组受试者的血清总25-羟维生素D、血清雌二醇水平和经会阴二维超声中膀胱尿道后角的特点。采用受试者工作特征(receiver operating characteristic,ROC)曲线分析上述各项指标单独和联合检测的诊断效能。结果:病例组平均年龄(56.97±7.60)岁,体重指数(body mass index,BMI)(26.04±3.35)kg/m^(2),产史(1.93±0.74)次;对照组平均年龄(53.50±6.95)岁,体重指数(24.53±3.53)kg/m^(2),产史(1.63±0.72)次,2组年龄、产史、BMI比较差异无统计学意义(P>0.05)。病例组血清总25-羟维生素D及血清雌二醇水平较对照组显著降低(P<0.05)。病例组在静息状态下及最大Valsalva动作时膀胱尿道后角较对照组明显增大,且2组患者在行Valsalva动作时,病例组的膀胱尿道后角旋转角较对照组显著增大(P<0.05)。经ROC曲线分析发现,血清总25-羟基维生素D、血清雌二醇联合膀胱尿道后角诊断女性SUI的效能明显优于各单项指标诊断。结论:血清总25-羟维生素D、血清雌二醇、膀胱尿道后角可在女性SUI诊断方面提供一定帮助,且三者联合应用更具有临床诊断价值。Objective:To explore the clinical value of total serum 25-hydroxyvitamin D,estradiol,and the posterior angle of the bladder-urethra in diagnosing female patients with stress urinary incontinence(SUI).Methods:A total of 30female patients with SUI admitted to the Central Theater General Hospital from June to September 2024were selected as the case group,while 30healthy women without SUI were included as the control group.The total serum 25-hydroxyvitamin D,estradiol levels,and the characteristics of the posterior angle of the bladder-urethra observed via transperineal 2Dultrasound were compared between the two groups.The diagnostic efficacy of each indicator individually and in combination was analyzed using receiver operating characteristic(ROC)curves.Results:The average age of the case group was(56.97±7.60)years old,with a body mass index(BMI)of(26.04±3.35)kg/m^(2) and a childbirth history of(1.93±0.74)times.The control group had an average age of(53.50±6.95)years old,a BMI of(24.53±3.53)kg/m^(2),and a childbirth history of(1.63±0.72)times.No statistically significant differences were found between the two groups in terms of age,childbirth history,or BMI(P>0.05).Total serum 25-hydroxyvitamin D and estradiol significantly decreased in the case group compared to the control group(P<0.05).Compared to the control group,the posterior angle of the bladder-urethra notably increased in the case group at rest and during maximum Valsalva maneuver,and the posterior angle rotation of the bladder-urethra was significantly greater in the case group during Valsalva maneuver(P<0.05).ROC curve analysis revealed that the combined assessment of total serum 25-hydroxyvitamin D,estradiol,and the posterior angle of the bladder-urethra had a significantly superior diagnostic efficacy for female patients with SUI compared to any individual indicator.Conclusion:Total serum 25-hydroxyvitamin D,estradiol and the posterior angle of the bladder-urethra may be effective in diagnosing female patients with SUI,and the combination of the t

关 键 词：压力性尿失禁 女性 25-羟维生素D 雌二醇 膀胱尿道后角 

分 类 号：R694.5[医药卫生—泌尿科学]