G蛋白偶联受体120在呼吸系统疾病中的作用  

Role of G protein-coupled receptor 120 in respiratory diseases

作　　者：赵妍妍 张丽君 张小春 梁向艳 赵玉峰[1] ZHAO Yanyan;ZHANG Lijun;ZHANG Xiaochun;LIANG Xiangyan;ZHAO Yufeng(Institute of Basic Medical Sciences,Xi′an Medical University,Xi′an 710021,China)

机构地区：[1]西安医学院基础医学研究所,陕西西安710021

出　　处：《基础医学与临床》2025年第2期244-248,共5页Basic and Clinical Medicine

基　　金：陕西省教育厅专项科研计划项目(22JK0553)。

摘　　要：G蛋白偶联受体120(GPR120)是长链游离脂肪酸的细胞膜受体,表达于呼吸系统的肺泡巨噬细胞和气道上皮Club细胞。GPR120激活可减轻呼吸道炎性反应,改善气道高反应性,促进Club细胞增殖,加速呼吸道上皮修复,从而减轻支气管哮喘和急性肺损伤。G protein-coupled receptor 120(GPR120)is one of the membrane receptors for long chain free fatty acids and is distributed in alveolus macrophages and airway epithelial Club cells.GPR120 activation alleviates the inflammation of respiratory tract,improves airway hyper-responsiveness,stimulates proliferation of Club cells and promotes the repair of respiratory epithelium,which may attenuate asthma and acute lung injury.

关 键 词：GPR120 呼吸系统 气道上皮 

分 类 号：R322.3[医药卫生—人体解剖和组织胚胎学]