Pleckstrin同源域家族A成员1在代谢性疾病中的作用  

The role of pleckstrin homology-like domain family A member 1 in metabolic diseases

作　　者：胡艳敏 彭丽娜[2] 杨勇[2] 向韵瑄 常晓悦 HU Yanmin;PENG Lina;YANG Yong;XIANG Yunxuan;CHANG Xiaoyue(Baotou Clinical Medical College,Inner Mongolia Medical University,Baotou 014040;Department of Pulmonary and Critical Care Medicine,Baotou Central Hospital,Baotou 014040,China)

机构地区：[1]内蒙古医科大学包头临床医学院,包头014040 [2]包头市中心医院呼吸与危重症医学科,包头014040

出　　处：《基础医学与临床》2025年第2期268-272,共5页Basic and Clinical Medicine

基　　金：包头市卫生健康科技计划项目(2024wsjkkj10)。

摘　　要：Pleckstrin同源域家族A成员1(PHLDA1)是一种促凋亡因子,也是代谢性疾病的关键调节剂。在肥胖相关疾病中,PHLDA1可以通过抑制固醇调控元素结合蛋白1(SREBP-1)的表达而减少肝三酰甘油的产生,也可通过抑制过氧化物酶体增殖剂激活受体γ(PPARγ)减少脂肪形成,但在心脑血管疾病中,却通过抑制PPARγ而增加血管钙化,刺激内质网应激反应(ERS)及线粒体功能障碍的产生,进而加重心脑缺血再灌注损伤。PHLDA1所表现出的双重作用也在肿瘤中得到印证。总之,PHLDA1作为多功能因子通过多种机制发挥不同作用。Pleckstrin homology-like domain family A member 1(PHLDA1)is a pro-apoptotic factor as well as a key regulator of metabolic diseases.In obesity-related diseases,PHLDA1 can reduce liver triglyceride production through inhibition of the expression of sterol regulatory-element binding proteins-1(SREBP-1),and reduce fat synthesis through inhibition of peroxisome proliferator-activated receptorγ(PPARγ).However,in cardiovascular diseases,PHLDA1 increases vascular calcification,dysfunction,thereby aggravates ischemia-reperfusion injury in the heart and brain.The dual role of PHLDA1 has also been confirmed in tumors.In summary,PHLDA1,as a multifunctional factor,plays different functional roles through various mechanisms.

关 键 词：pleckstrin同源域家族A成员1 内质网应激反应 肥胖 心血管疾病 

分 类 号：R589.2[医药卫生—内分泌] R541[医药卫生—内科学] R730[医药卫生—临床医学]