Lp-PLA_(2)、HGI与2型糖尿病视网膜病变严重程度的关系研究  

Relationship between Lp-PLA_(2),HGI and severity of type 2 diabetic retinopathy

作　　者：彭少林 杨水冰 杨井金 陆小玉 张美彪 PENG Shaolin;YANG Shuibing;YANG Jingjin;LU Xiaoyu;ZHANG Meibiao(Department of Endocrinology and Metabolism,General Hospital of Hunan Medical University/the Fourth Affiliated Hospital of Jishou University/Huaihua Sub-center of National Clinical Research Center for Metabolic Diseases/Huaihua Sub-center of National Metabolic Management Center(MMC),Huaihua,Hainan 418000,China;Department of Endocrinology and Metabolism,the Second People′s Hospital of Hainan Province,Wuzhishan,Hainan 572299,China)

机构地区：[1]湖南医药学院总医院/吉首大学附属第四医院内分泌代谢科/国家代谢性疾病临床医学研究中心怀化分中心/国家标准化代谢性疾病管理中心(MMC)怀化分中心,湖南怀化418000 [2]海南省第二人民医院内分泌代谢科,海南五指山572299

出　　处：《国际检验医学杂志》2025年第2期141-145,共5页International Journal of Laboratory Medicine

基　　金：湖南省卫健委科研计划项目(D202303068330);怀化市科技创新计划项目(2021R3119);吉首大学校级科研项目(Jdzd21039,202220)。

摘　　要：目的探讨脂蛋白相关的磷脂酶A2(Lp-PLA_(2))、糖化血红蛋白指数(HGI)与2型糖尿病视网膜病变严重程度的关系。方法选取2021年1月至2022年6月于湖南医药学院总医院住院的120例2型糖尿病患者作为研究对象,将其分为2型糖尿病无视网膜病变组(NDR组,n=45)、非增殖期糖尿病视网膜病变组(NPDR组,n=45)和增殖期视网膜病变组(PDR组,n=30)。同期随机抽取该院50例体检健康者作为对照组。收集并比较各组临床资料和Lp-PLA_(2)、HGI水平,并分析HGI及Lp-PLA_(2)水平与病情严重程度的相关性。结果NDR组、NPDR组、PDR组Lp-PLA_(2)、HGI均高于对照组(P<0.05)。高Lp-PLA组(H-Lp-PLA_(2)组)、高H-HGI组(H-HGI组)NPDR、PDR患者比例高于低HGI组(L-HGI组)和低L-Lp-PLA_(2)组(L-Lp-PLA_(2)组),差异有统计学意义(P<0.05)。多元Logistic回归分析显示,Lp-PLA_(2)、HGI是DR的危险因素(P<0.05),与2型糖尿病视网膜病变严重程度呈正相关(P<0.05)。结论HGI、Lp-PLA_(2)与2型糖尿病视网膜病变严重程度密切相关,可作为评估病情严重程度的新指标。Objective To investigate the correlation between lipoprotein-associated phospholipase A2(Lp-PLA_(2)),hemoglobin glycotion index(HGI)and the severity of type 2 diabetic retinopathy.Methods A total of 120 patients with type 2 diabetes mellitus who were hospitalized in the General Hospital of Hunan Medical University from January 2021 to June 2022 were selected and divided into type 2 diabetes without retinopathy group(NDR group,n=45),non-proliferative diabetic retinopathy group(NPDR group,n=45)and proliferative diabetic retinopathy group(PDR group,n=30).In the same period,50 healthy subjects were randomly selected as control group.The clinical data,Lp-PLA_(2) and HGI levels of each group were collected and compared,and the correlation between different HGI and Lp-PLA_(2) levels and the severity of the disease was analyzed.Results The levels of Lp-PLA_(2) and HGI in NDR,NPDR and PDR groups were higher than those in control group(P<0.05).The proportion of patients with NPDR and PDR in high-Lp-PLA group(H-Lp-PLA_(2) group)and high-HGI group(H-HGI group)were higher than those in low-HGI group(L-HGI group)and low-Lp-PLA_(2) group(L-Lp-PLA_(2) group),and the differences were statistically significant(P<0.05).Multiple Logistic regression analysis showed that Lp-PLA_(2) and HGI were risk factors for DR(P<0.05),and were positively correlated with the severity of type 2 diabetic retinopathy(P<0.05).Conclusion HGI and Lp-PLA_(2) are closely related to the severity of retinopathy in type 2 diabetes mellitus,and may be used as new indicators to predict the severity of the disease.

关 键 词：糖尿病视网膜病变 脂蛋白相关的磷脂酶A2 糖化血红蛋白指数 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]