温肾养肝中药联合头针辅治老年帕金森病合并肝肾不足型失眠症的临床疗效  

Clinical efficacy of warm kidney and liver nourishing traditional Chinese medicine combined with head acupuncture in the treatment of elderly Parkinson′s disease patients complicated with insomnia with hepatic and renal insufficiency type

作　　者：王亚伟 吕祥龙 WANG Yawei;LYU Xianglong(Chuzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Anhui University of Chinese Medicine,Anhui Province,Chuzhou 239000,China)

机构地区：[1]安徽中医药大学附属滁州中西医结合医院,安徽省滁州市239000

出　　处：《临床合理用药》2025年第3期13-16,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：安徽省中医药传承创新科研项目(2020ccyb27);滁州市中医药学会科研计划项目(2021XH09)。

摘　　要：目的 观察温肾养肝中药联合头针辅治老年帕金森病(PD)合并肝肾不足型失眠症的临床疗效。方法 选取2022年6月—2023年6月安徽中医药大学附属滁州中西医结合医院收治的老年PD合并肝肾不足型失眠症患者80例,按照随机筛选法分为试验组与对照组,各40例。对照组给予多巴丝肼片+阿普唑仑片治疗,试验组在对照组基础上加用温肾养肝中药联合头针治疗,2组均治疗4个疗程。比较2组临床疗效,治疗前后统一帕金森评定量表(UPDRS)评分、匹兹堡睡眠质量指数(PSQI)评分、入睡时间评分、睡眠效率评分、血清学指标[超氧化物歧化酶(SOD)、丙二醛(MDA)、白介素(IL)-1β、IL-8、降钙素原(PCT)、C反应蛋白(CRP)]。结果 试验组治疗总有效率高于对照组(90.00%vs. 70.00%,χ^(2)=5.000,P=0.025)。治疗4个疗程后,2组UPDRS、PSQI、入睡时间、睡眠效率评分均低于治疗前,且试验组低于对照组(P<0.05或P<0.01);2组血清SOD水平高于治疗前,血清MDA、IL-1β、IL-8、PCT、CRP水平低于治疗前,且试验组升高/降低幅度大于对照组(P<0.01)。结论 在常规西药治疗基础上,采用温肾养肝中药联合头针可明显改善老年PD合并肝肾不足型失眠症患者临床症状,提高睡眠质量,延长睡眠时间,改善氧化应激反应及降低炎性因子水平。Objective To observe the clinical efficacy of warm kidney and liver nourishing traditional Chinese medicine combined with head acupuncture in the treatment of elderly PD patients complicated with insomnia with hepatic and renal insufficiency type.Methods A total of 80 elderly patients with PD complicated with insomnia with hepatic and renal insufficiency type who were admitted to Chuzhou Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Anhui University of Chinese Medicine from June 2022 to June 2023 were selected,and they were divided into the experimental group and the control group,with 40 cases in each group.The control group was treated with levodopa and benserazide hydrochloride tablets+alprazolam tablets,and the experimental group was treated with warm kidney and liver nourishing traditional Chinese medicine combined with head acupuncture on the basis of the control group,and both groups were treated for 4 courses of treatment.The clinical efficacy,UPDRS score,PSQI score,sleep onset time score,sleep efficiency score,serological indexes(SOD,MDA,IL-1β,IL-8,PCT,CRP)before and after treatment were compared between the two groups.Results The total effective rate of treatment in the experimental group was higher than that in the control group(90.00%vs.70.00%,χ^(2)=5.000,P=0.025).After 4 courses of treatment,the UPDRS,PSQI,sleep onset time and sleep efficiency scores of the two groups were lower than those before treatment,and the experimental group were lower than those of the control group(P<0.05 or P<0.01).The serum level of SOD in the two groups was higher than that befor treatment,and the serum levels of MDA,IL-1β,IL-8,PCT and CRP in the two groups were lower than those before treatment,and the increase/decrease in the experimental group were higher than those in the control group(P<0.01).Conclusion On the basis of conventional western medicine treatment,the use of warm kidney and liver nourishing traditional Chinese medicine combined with head acupuncture can significantly imp

关 键 词：帕金森病 失眠症 肝肾不足型 老年人 温肾养肝中药 头针 氧化应激指标 炎性因子 

分 类 号：R277.7[医药卫生—中医学] R256.23