北青龙衣中二氯甲烷萃取部位的化学成分研究  

Study on the Chemical Components of Dichloromethane Extract Area of Northern Walnut Peel

作　　者：付起凤[1] 赵妍[2] 苏阳[2] 金阳[2] 孙杰 张晓娟[1] 孟健男[1] 唐晓巍 王萍 周媛媛[2] FU Qifeng;ZHAO Yan;SU Yang;JIN Yang;SUN Jie;ZHANG Xiaojuan;MENG Jiannan;TANG Xiaowei;WANG Ping;ZHOU Yuanyuan(Heilongjiang University of Chinese Medicine,Harbin150040,China;Key Laboratory of Basic and Applied Research of Northern Medicine of Ministry of Education,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Heilongjiang Academy of Traditional Chinese Medicine,Harbin 150036,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学教育部北药基础与应用研究重点实验室,黑龙江哈尔滨150040 [3]黑龙江省中医药科学院,黑龙江哈尔滨150036

出　　处：《中医药信息》2025年第2期30-33,64,共5页Information on Traditional Chinese Medicine

基　　金：黑龙江省自然科学基金联合基金培育项目(PL2024H233);黑龙江省“双一流”学科协同创新成果建设项目(LJGXCG2022-096);黑龙江省“头雁”团队支持项目(黑龙江省头雁行动领导小组文件[2019]5号)。

摘　　要：目的:研究北青龙衣二氯甲烷萃取部位的化学成分。方法:运用硅胶柱色谱、ODS柱色谱、中压液相色谱和半制备高效液相色谱等方法对北青龙衣进行分离纯化,随后依据理化性质及MS、NMR等波谱数据,对所分离出的化学成分开展结构鉴定工作。结果:从北青龙衣药材中分离并鉴定了12个化合物,分别鉴定为3-甲氧基胡桃醌(1)、2,5,8-三羟基-3-甲氧基-1,4-萘醌(2)、4-甲氧基-5-羟基-1-四氢萘酮(3)、(4S)-4,8-二羟基-1-四氢萘酮(4)、gingerenone A(5)、枫杨醌(6)、Platycary A(7)、Platycary D(8)、算盘子酮(9)、圣草素(10)、芹菜素(11)、6,5′-二异戊烯基槲皮素(12)。结论:化合物5、7、8、9、10为首次从北青龙衣中分离得到。Objective:To study the chemical components of the dichloromethane extract area of Northern Walnut Peel.Methods:The separation and purification of the chemical components from Northern Walnut Peel were carried out using silica gel column chromatography,ODS column chromatography,medium-pressure liquid chromatography,and semipreparative high-performance liquid chromatography.The structures of the isolated compounds were identified based on their physicochemical properties and spectral data(MS,NMR).Results:Twelve compounds were isolated and identified from Northern Walnut Peel,including 3-methoxyjuglone(1),2,5,8-trihydroxy-3-methoxy-1,4-naphthoquinone(2),4-methoxy-5-hydroxy-1-tetralone(3),(4S)-4,8-dihydroxy-1-tetralone(4),gingerenone A(5),maplestone(6),Platycary A(7),Platycary D(8),pseudoginsengone(9),Saintgrassin(10),apigenin(11),6,5'-diisoprenylquercetin(12).Conclusion:Compounds 5,7,8,9,and 10 were first isolated from Northern Walnut Peel.

关 键 词：北青龙衣 化学成分 提取分离 结构研究 

分 类 号：R28[医药卫生—中药学]