中药单体治疗肌少症的机制研究进展  

Research Progress on Mechanisms of Traditional Chinese Medicine Monomers in the Treatment of Sarcopenia

作　　者：刘芳 黄楠 杨佳明 陈龙 涂嘉欣 钟燕彪 罗云 王茂源 LIU Fang;HUANG Nan;YANG Jiaming;CHEN Long;TU Jiaxing;ZHONG Yanbiao;LUO Yun;WANG Maoyuan(Gannan Medical University,Ganzhou 341000,China;The First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China;Ganzhou Intelligent Rehabilitation Technology Innovation Center,Ganzhou 341000,China;Ganzhou Key Laboratory of Rehabilitation Medicine,Ganzhou 341000,China)

机构地区：[1]赣南医科大学,江西赣州341000 [2]赣南医科大学第一附属医院,江西赣州341000 [3]赣州市智能康复技术创新中心,江西赣州341000 [4]赣州市康复医学重点实验室,江西赣州341000

出　　处：《中医药信息》2025年第2期82-87,共6页Information on Traditional Chinese Medicine

基　　金：国家自然科学基金项目(82060420);江西省自然科学基金项目(20212BAB206004);赣州市科技局重大项目(2023LNS37155);赣南医科大学心脑血管疾病防治教育部重点实验室(NX202022)。

摘　　要：肌少症是一种骨骼肌疾病,主要表现为骨骼肌质量和功能逐渐下降,与炎症反应、氧化应激反应、线粒体功能障碍、肌细胞自噬改变及卫星细胞功能受损有关。肌少症属“消瘅”“痿症”“虚劳”范畴,通过综述中药单体治疗肌少症机制研究的相关文献,发现中药单体防治肌少症疗效显著,且相较于激素具有更高的安全性,中药单体如姜黄素、白术内酯Ⅰ、淫羊藿苷、毛蕊异黄酮等,能够改善肌肉卫星细胞功能、线粒体功能、炎症与氧化应激反应、介导胰岛素抵抗,延缓骨骼肌萎缩,增加骨骼肌力量和改善骨骼肌功能,从而防治肌少症的发生和发展。Sarcopenia is a skeletal muscle disease characterized by the progressive decline in skeletal muscle mass and function.It is associated with inflammatory responses,oxidative stress,mitochondrial dysfunction,autophagy changes in muscle cells,and satellite cell impairment.Classified under the categories of"wilting syndrome",and"consumptive disease"in Traditional Chinese Medicine(TCM),we found that sarcopenia can be effectively prevented and treated with TCM monomers.Compared with hormones,TCM monomers offer significant therapeutic benefits and greater safety.Monomers such as curcumin,atractylenolide I,icariin,and calycosin have been shown to improve muscle satellite cell function,mitochondrial activity,inflammatory and oxidative stress responses,and insulin resistance.They also delay skeletal muscle atrophy,enhance muscle strength,and improve muscle function,thereby preventing and mitigating the development of sarcopenia.

关 键 词：中药 肌少症 骨骼肌萎缩 骨骼肌再生 机制 研究进展 

分 类 号：R274.9[医药卫生—中西医结合]