氨溴索注射液联合金振口服液治疗儿童支原体肺炎的临床疗效  

Clinical effect of ambroxol injection combined with Jinzhen Oral Solution for the treatment of pediatric pneumonia caused by mycoplasma infection

作　　者：刘艳霖 史曼 Liu Yanlin;Shi Man(Department of Paediatrics,Xiayi County People′s Hospital,Shangqiu,Henan 476400,China)

机构地区：[1]夏邑县人民医院儿二科,河南商丘476400

出　　处：《中国药物与临床》2025年第2期73-77,共5页Chinese Remedies & Clinics

摘　　要：目的探讨氨溴索注射液联合金振口服液治疗儿童支原体肺炎的临床疗效及对患儿肺功能与炎性反应的影响。方法根据随机数字表法,将2021年3月至2023年10月河南省夏邑县人民医院收治的支原体肺炎患儿73例分为对照组(36例)和观察组(37例)。患儿入院后均施以抗感染、退热等常规治疗,对照组患儿给予盐酸氨溴索注射液静脉注射治疗,观察组在对照组基础上联合金振口服液口服治疗,均持续治疗1周。比较2组患儿的临床疗效与各种症状的缓解时间,治疗前及治疗后的肺功能和炎性反应以及不良反应情况。结果治疗后对照组临床总有效率为77.8%(28/36),观察组临床总有效率为97.3%(36/37),观察组高于对照组(χ^(2)=4.753,P<0.05)。通过治疗,观察组患儿发热、咳嗽、咳痰、气喘症状缓解时间均低于对照组(t=4.263、4.316、5.095、9.149,P均<0.05)。通过治疗,2组肺功能呼气峰流速、第1秒用力呼气容积、第1秒用力呼气容积与用力肺活量比值均较治疗前提高,观察组较对照组高(t=6.165、55.207、5.094,P均<0.05)。治疗后,2组淀粉样蛋白(SAA)、白细胞介素(IL)-2、降钙素原(PCT)水平均下降,观察组患儿较对照组下降明显(t=10.834、5.900、9.101,P均<0.05)。结论氨溴索注射液联合金振口服液在儿童支原体肺炎治疗中效果显著,可缓解患儿发热、咳嗽等症状,对肺功能的恢复有积极作用,能减轻患儿炎性反应,且不增加患儿不良反应。Objective To investigate the clinical efficacy of ambroxol injection combined with Jinzhen Oral Solution in pediatric pneumonia infected by mycoplasma and its effect on pulmonary function and inflammatory reaction.Methods According to the random number table method,a total of 73 pediatric patients with pneumonia caused by Mycoplasma pneumoniae admitted to Xiayi County People′s Hospital between March 2021 and October 2023 were divided into a control group(36 cases)and an observation group(37 cases).After admission,all children were given routine treatments such as anti-infective therapy and fever reduction.The control group was treated with intravenous injection of ambroxol hydrochloride injection,while the observation group was additionally given Jinzhen Oral Solution orally on this basis.Both treatments lasted for one week.The clinical efficacy,the relief time of various symptoms,lung function and inflammatory response before and after treatment,as well as adverse reactions were compared between the two groups.Results The clinical total effective rates of the control group and the observation group after treatment were 77.8%(28/36)and 97.3%(36/37),respectively.The clinical total effective rate of the observation group was significantly higher(χ^(2)=4.753,P<0.05).After treatment,the relief time of fever,cough,sputum production,and asthma symptoms in the observation group was significantly lower than that in the control group(t=4.263,4.316,5.095,9.149,all P<0.05).The peak expiratory flow rate,forced expiratory volume in the first second,and the ratio of forced expiratory volume to forced vital capacity in the first second were all significantly improved in both groups,and the effect of the observation group was more significant(t=6.165,55.207,5.094,all P<0.05).After treatment,the levels of various inflammatory factors(SAA,IL-2,PCT)in both groups decreased,and the effect was more significant in the observation group(t=10.834,5.900,9.101,all P<0.05).Conclusion The combination of ambroxol injection and Jinzhen Ora

关 键 词：肺炎 支原体 氨溴索 呼吸功能试验 

分 类 号：R725.6[医药卫生—儿科]