运用超声心动图多模态参数评估肥厚型心肌病患者早期左心室功能变化  

Assessment of early left ventricular functional changes in HCM patients by multimodality echocardiographic parameters

作  者:张艳娟[1] 王璎瑛[2] 赵迪 吴红平[1] 孙伟[1] 雍永宏[1] ZHANG Yanjuan;WANG Yingying;ZHAO Di;WU Hongping;SUN Wei;YONG Yonghong(Department of Cardiology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China;Department of Geriatrics,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区:[1]南京医科大学第一附属医院心血管内科,江苏南京210029 [2]南京医科大学第一附属医院老年医学科,江苏南京210029

出  处:《南京医科大学学报(自然科学版)》2025年第2期240-244,259,共6页Journal of Nanjing Medical University(Natural Sciences)

基  金:国家自然科学基金(82270362)。

摘  要:目的:运用超声心动图的多模态参数评估肥厚型心肌病(hypertrophic cardiomyopathy,HCM)患者早期左心室收缩及舒张功能的变化。方法:选取2019年10月—2021年6月在南京医科大学第一附属医院门诊就诊的HCM患者共54例,其中包括非梗阻性HCM患者34例和梗阻性HCM患者20例,同时选择30例正常人作为对照组,运用超声心动图的多模态参数,比较3组间左心室收缩及舒张功能的变化。结果:HCM患者左室收缩功能及舒张功能均降低,其中梗阻性HCM患者左心室整体长轴应变(global longitudinal strain,GLS)、整体做功指数(global work index,GWI)、整体有效功(global constructive work,GCW)、整体做功效率(global work efficiency,GWE)降低更为明显,整体无效功(global waste work,GWW)在3组间差异无统计学意义。结论:超声心动图的多模态参数可以早期全面地评价HCM患者左室收缩及舒张功能的受损情况,为临床诊疗及预后提供重要依据。Objective:The aim of this study was using multimodality echocardiographic parameters to evaluate early changes in systolic and diastolic functions of left ventricle in patients with hypertrophic cardiomyopathy(HCM).Methods:A total of 54 HCM patients were selected,including 34 with non⁃obstructive HCM patients and 20 with obstructive HCM patients,who visited the outpatient department of the First Affiliated Hospital of Nanjing Medical University from October 2019 to June 2021.Additionally,30 healthy individuals were chosen as a control group.Multimodality echocardiographic parameters were used to compare the changes in left ventricular systolic and diastolic functions among three groups.Results:HCM patients exhibited reduced left ventricular systolic and diastolic function.Obstructive HCM patients showed more significant reduction in global longitudinal strain(GLS),global work index(GWI),global constructive work(GCW),and global work efficiency(GWE).The difference in global waste work(GWW)among the three groups was not statistically significant.Conclusion:Multimodality echocardiographic parameters can comprehensively evaluate the early impairment of left ventricular systolic and diastolic functions in HCM patients,providing important basis for clinical diagnosis,treatment,and prognosis as early as possible.

关 键 词:压力-应变环 肥厚型心肌病 左心室做功 左心室舒张功能 

分 类 号:R445.1[医药卫生—影像医学与核医学]

 

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