甲状腺激素与心脏纤维化研究进展  

Research progress on thyroid hormone and cardiac fibrosis

作　　者：陆瑄贝 王晓东[1] LU Xuanbei;WANG Xiaodong(Department of Endocrinology,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院内分泌科,江苏南京210029

出　　处：《南京医科大学学报(自然科学版)》2025年第2期278-284,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省卫生健康委员会基金(ZDA2020035)。

摘　　要：心衰是各种心脏疾病的不良结局,其病理基础之一是进行性间质纤维化所致的结构和功能改变。纤维化由成纤维细胞介导并激活,产生细胞外基质,过度激活会使基质蛋白积累,引发病理性纤维化,最终导致器官损伤。甲状腺激素是心血管系统的重要调节因子,亚临床和显性甲状腺功能减退通过一系列病理性机制促进心脏纤维化,甲状腺激素替代疗法也被考虑用于心脏功能保护。文章对甲状腺激素与心脏纤维化的研究现状进行了阐述。Heart failure is a detrimental consequence of various cardiac diseases,and one of its pathological bases is the structural and functional changes caused by progressive interstitial fibrosis.Fibroblasts mediate and activate fibrosis to generate extracellular matrix,and excessive activation leads to the accumulation of matrix proteins,ultimately resulting in pathological fibrosis and organ damage.Thyroid hormone plays a crucial role in regulating the cardiovascular system,while subclinical and overt thyroid disorders impact cardiac fibrosis through a series of pathological mechanisms.Thyroid hormone replacement therapy is also considered for safeguarding cardiac function.This review is to provide an overview of current research on thyroid hormones and cardiac fibrosis.

关 键 词：甲状腺激素 成纤维细胞 心脏纤维化 心衰 甲状腺疾病 

分 类 号：R581[医药卫生—内分泌]