RNA修饰与肾脏疾病  

RNA modification and kidney disease

作　　者：汪居安 郭钊辰(综述) 鲍浩(审校) WANG Juan;GUO Zhaochen;BAO Hao(National Clinical Research Center for Kidney Diseases,Jinling Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210016,China)

机构地区：[1]南京大学医学院附属金陵医院(东部战区总医院)国家肾脏疾病临床医学研究中心,南京210016

出　　处：《肾脏病与透析肾移植杂志》2024年第6期555-560,共6页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：江苏省科技计划专项资金社会发展面上项目(BE2022825);江苏省卫生健康委医学科研重点项目(K2023003)。

摘　　要：RNA修饰是在碱基的不同原子上的化学修饰,迄今为止,已鉴定出超过170种RNA化学修饰。越来越多的研究表明,RNA修饰在肾脏疾病的发生、发展和转归中起着不可或缺的作用。全面了解肾脏病中的RNA修饰有助于理解肾脏病的发病与转归机制。本文总结了常见的4种RNA修饰:N6-甲基腺苷(m6A)修饰、5-甲基胞嘧啶(m5C)修饰、腺苷-肌苷(A-to-I)编辑和假尿苷(Ψ)的基本概念及其在肾脏疾病中的调节作用,旨在为临床和基础研究提供参考。RNA modification is a chemical modification that occurs at different atoms of a base,and more than 170 modifications have been identified on RNA to date.A growing body of research has shown that RNA modification plays an indispensable role in the occurrence,development and prognosis of kidney disease.A comprehensive understanding of RNA modification in kidney disease can help us understand the pathogenesis and prognosis of kidney disease.This article summarizes basic concept and regulatory role of four common RNA modifications:N6-methyladenosine(m6A)modification,5-methylcytidine(m5C)modification,adenosine to inosine(A-to-I)editing,and pseudouridylation(Ψ),aiming to provide reference for clinical and basic research.

关 键 词：RNA修饰 N6-甲基腺苷修饰 5-甲基胞嘧啶修饰 腺苷-肌苷编辑 假尿苷 肾脏病 

分 类 号：R692[医药卫生—泌尿科学]