荧光原位杂交检测在系统性轻链型淀粉样变性诊治中的意义  

Fluorescence in situ hybridization in systemic light chain amyloidosis

作　　者：任苡萱(综述) 黄湘华(审校) REN Yixuan;HUANG Xianghua(National Clinical Research Center for Kidney Diseases,Jinling Hospital,Jinling Clinical Medical College,Nanjing University of Chinese Medicine,Nanjing 210016,China)

机构地区：[1]南京中医药大学金陵临床医学院(东部战区总医院)国家肾脏疾病临床医学研究中心,南京210016

出　　处：《肾脏病与透析肾移植杂志》2024年第6期567-572,共6页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金面上项目(82270767);江苏省重点研发计划社会发展面上项目(BE2023797)。

摘　　要：荧光原位杂交检测是一种分子细胞遗传学诊断技术,能够为病理诊断和临床治疗提供更为准确的依据。该技术已广泛运用于多发性骨髓瘤的诊治过程中,但在系统性轻链型(AL型)淀粉样变性中尚未得到广泛应用。本文将对常见细胞遗传异常类型对患者治疗方案选择及生存预后的影响作一综述,以期为AL型淀粉样变性的诊治提供新思路。Fluorescence in situ hybridization is a molecular cytogenetic diagnostic technique,which can provide a more accurate basis for pathological diagnosis and clinical treatment.This technique has been widely used in the diagnosis and treatment of multiple myeloma but has not been widely used in systemic light chain(AL)amyloidosis.This article will review the effects of common types of cytogenetic abnormalities on the choice of treatment and survival prognosis of patients.

关 键 词：系统性轻链型淀粉样变性 荧光原位杂交 治疗 

分 类 号：R597.2[医药卫生—内科学] R692[医药卫生—临床医学]