调节性B细胞在同种异体肾移植免疫中的研究进展  

Regulatory B cells in renal allograft immunology

作　　者：吴黄婕(综述) 曹红娣(审校)[1] WU Huangjie;CAO Hongdi(Nephrology Center,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210003,China)

机构地区：[1]南京医科大学第二附属医院肾脏病中心,南京210003

出　　处：《肾脏病与透析肾移植杂志》2024年第6期585-590,共6页Chinese Journal of Nephrology,Dialysis & Transplantation

基　　金：国家自然科学基金面上项目(82070761);南京医科大学科技发展基金(NMUC2022007A)。

摘　　要：肾移植是终末期肾病患者长期高质量生存的首选治疗方法,该领域的重点研究目标之一是寻找在受体中诱导同种异体移植物耐受的可靠方法。长期以来,B细胞被认为通过分泌抗体在适应性免疫系统中发挥关键作用,对患有自身免疫性疾病的个体有害。然而,近年来多项研究表明,并非所有B细胞亚群均增加免疫反应。调节性B细胞(Bregs)可通过分泌白细胞介素10等抑制性细胞因子对自身免疫性疾病发挥保护作用,这可能有助于发现新的免疫治疗方法,以实现移植中的免疫耐受。本文总结了Bregs的起源、表型和免疫调节机制,着重阐述其在肾移植免疫中的重要作用及潜在治疗价值。Kidney transplantation is the preferred treatment method for long-term high quality survival in patients with end-stage renal disease,and one of the key research goals in this area is to find reliable ways to induce allograft tolerance in recipients.B cells have long been thought to play a critical role in the adaptive immune system by secreting antibodies,which are harmful to individuals with autoimmune diseases.However,in recent years,several studies have shown that not all B cell subsets increase the immune response.Regulatory B cells(Bregs)may exert protective effects against autoimmune diseases by secretion of inhibitory cytokines such as IL-10,which may help in the discovery of new immunotherapies to achieve immune tolerance in transplantation.This article summarizes the discovery,phenotype,and immunomodulatory mechanisms of Bregs,and focuses on their important role and potential therapeutic value in kidney transplantation immunity.

关 键 词：调节性B细胞 肾移植 免疫 移植耐受 

分 类 号：R699.2[医药卫生—泌尿科学]