利咽止咳喷雾剂止咳祛痰及抗免疫实验研究  

Experimental Study on Relieving Cough and Expelling Phlegm and Anti-immunity of LiYan ZhiKe Spray

作　　者：吕栋 梁一博 王奕匀 沈薇 王珺 程鹏飞 施小宁[2] 罗宗明 火明 LV Dong;LIANG Yi-bo;WANG Yi-yun;SHEN Wei;WANG Jun;CHENG Peng-fei;SHI Xiao-ning;LUO Zong-ming;HUO Ming(Gansu Institute of Drug Control,Lanzhou 730070,China;Gansu University Chinese Medicine,Lanzhou 730000,China;Gansu Hongen Folk Chinese Herbal Medicine Research Institute,Lanzhou 730010,China;The First Hospitai of Lanzhou University,Lanzhou 730030,China)

机构地区：[1]甘肃省药品检验研究院,甘肃兰州730070 [2]甘肃中医药大学,甘肃兰州730000 [3]甘肃鸿恩民间中草药医研究所,甘肃兰州730010 [4]兰州大学第一附属医院,甘肃兰州730030

出　　处：《海峡药学》2024年第12期12-14,共3页Strait Pharmaceutical Journal

基　　金：甘肃省药品监督管理局科研项目(2022GSMPA0022,2022GSMPA0028,2023GSMPA063);甘肃省科技项目23JRRA1367。

摘　　要：目的通过动物实验,观察利咽止咳喷雾剂的止咳祛痰及抗免疫作用。方法KM种小鼠及SD大鼠,雌雄各半,随机分为空白对照组,阳性组,供试品低、中、高剂量组;连续给药7天,观察利咽止咳喷雾剂对小鼠的咳嗽次数,咳嗽潜伏期,器官酚红排泄量,及对大鼠胸腺指数和脾脏指数的影响。结果与模型组比较,给药组和空白对照组小鼠的咳嗽次数无显著型差异(P>0.05),咳嗽潜伏期上调(P<0.05或P<0.01),供试品低、中剂量组及阳性组大鼠胸腺指数显著上调(P<0.01);与空白对照组比较,供试品低、中、高剂量组及阳性组小鼠器官酚红排泄量均显著增加(P<0.01)。结论利咽止咳喷雾剂可显著延长动物止咳潜伏期,增大器官酚红排泄量,对动物的免疫功能具有一定的改善作用。OBJECTIVE Through animals experiments,The antitussive and expectorant effects of LiYan ZhiKe spray was observed.METHODS KM mice and SD rats,half male and half female,randomly divided into blank control group,positive group,subjects low,medium and high dose groups;The drug was administered continuously for 7 days,the effects of LiYan ZhiKe spray on cough times,cough latency,organ phenol red excretion,and thymus and spleen index of rats were detected.RESULTS Compare with model group,there was no significant difference in the number of coughs between the administration group and the blank control group(P>0.05),but there were increased cough latency(P<0.05 or P<0.01).There was significant difference in thymus index between low dose group,medium dose group and positive group(P<0.01).Compared with blank control group,organ phenol red excretion in low,medium and high dose groups and positive group was increased(P<0.01).CONCLUSION LiYan ZhiKe spray can significantly prolong the cough latency in animals,increas organ phenol red excretion.It can improve the immune function of rats.

关 键 词：利咽止咳喷雾剂 止咳 祛痰 抗免疫 

分 类 号：R965[医药卫生—药理学]