A G3P[3]bat rotavirus can infect cultured human cholangiocytes and cause biliary atresia symptom in suckling mice  

作　　者：Pengfei Hao Zhaoxia Pang Qiaoqiao Qu Chunmei Cui Yuhang Jiang Jing Chen Zihan Gao Zhiqiang Xu Letian Li Ningyi Jin Chang Li 

机构地区：[1]State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases,Key Laboratory for Zoonosis Research,Ministry of Education,College of Veterinary Medicine,Jilin University,Changchun,130062,China [2]Research Unit of Key Technologies for Prevention and Control of Virus Zoonoses,Chinese Academy of Medical Sciences,Changchun Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Changchun,130122,China

出　　处：《Virologica Sinica》2024年第6期974-976,共3页中国病毒学(英文版)

摘　　要：Dear Editor,Rotavirus(RV),a member of the Reoviridae family,is non-enveloped virus with a genome consisting of 11 segments of double-stranded RNA.It possesses a three-layered shell structure,and can be classified into types A–L based on the VP6 serotype,with species A being the most common in mammals.Apart from causing severe diarrhea in infants and young animals,rotavirus is also identified as a potential cause of biliary atresia,a serious condition characterized by bile duct obstruction,leading to major complications such as growth retardation,jaundice,cirrhosis,liver failure,and death(Wang et al.,2020).Several strains,such as rhesus rotavirus(RRV),have been demonstrated to induce biliary atresia symptoms in BALB/c mice(Mohanty et al.,2020).Additionally,orthoreovirus type 3,another member of the Reoviridae family,has been identified as a causative agent of biliary atresia(Averbukh and Wu,2018).

关 键 词：BALB/C envelope 

分 类 号：R373[医药卫生—病原生物学]