脂质代谢途径对病毒复制的影响机制  

Influencing mechanism of lipid metabolism pathways on viral replication

作　　者：张宇 武艺 赵俊杰 李璐[1,2,3] 刘羿羿 钱晓影[4] 张焱如 孟凡华 曹俊伟 ZHANG Yu;WU Yi;ZHAO Junjie;LI Lu;LIU Yiyi;QIAN Xiaoying;ZHANG Yanru;MENG Fanhua;CAO Junwei(College of Life Science,Inner Mongolia Agricultural University,Hohhot 010018,China;Inner Mongolia Autonomous Region Key Laboratory of Biological Manufacturing,Hohhot 010018,China;Inner Mongolia Regional Specialty Livestock Biotechnology Innovation Team,Hohhot 010018,China;Hinggan League Agricultural and Animal Husbandry Research Institute,Hinggan League 137400,China;School of Medicine,Hainan Vocational University of Science and Technology,Haikou 571126,China)

机构地区：[1]内蒙古农业大学生命科学学院,呼和浩特010018 [2]内蒙古自治区生物制造重点实验室,呼和浩特010018 [3]内蒙古地区特色家畜生物技术创新团队,呼和浩特010018 [4]兴安盟农牧科学研究所,内蒙古兴安盟137400 [5]海南科技职业大学医药学院,海口571126

出　　处：《黑龙江畜牧兽医》2025年第2期22-26,共5页Heilongjiang Animal Science And veterinary Medicine

基　　金：内蒙古自然科学基金项目(2020MS03048)。

摘　　要：脂质代谢途径作为细胞代谢中重要的环节,不仅能为细胞生存提供能量,还在信号转导、蛋白质酰基化、细胞膜组成及合成必需脂肪酸等方面具有重要作用,是生物体不可或缺的一部分。病毒不仅能与宿主细胞膜上的脂质发生相互作用,还能利用脂质代谢途径调节脂质组成与代谢信号通路,在病毒的侵入、组装、出芽和释放过程中发挥至关重要的作用。为了了解脂质在病毒复制中的作用机制,本文阐述了脂质、病毒蛋白质棕榈酰化及脂滴在病毒不同生命周期中对病毒复制的影响,以期为抗病毒药物的研究提供新的思路。As an important part of cell metabolism,lipid metabolism pathway could not only provide energy for cell survival,but also play an important role in signal transduction,protein acylation,cell membrane composition and synthesis of essential fatty acids,which is an indispensable part of the organisms.Viruses could not only interact with lipids on the host cell membrane,but also use lipid metabolism pathways to regulate lipid composition and metabolic signaling pathways,which play a crucial role in the invasion,assembly,budding and release of viruses.In order to systematically understand the mechanism of lipids in viral replication,this paper expounded lipids,viral protein palmitoylation and lipid droplets in viral replication during different life cycles,in order to provide new ideas for the research of antiviral drugs.

关 键 词：病毒 脂质代谢 脂筏 棕榈酰化 脂滴 

分 类 号：Q955[生物学—动物学]