艾司洛尔联合替罗非班治疗急性心肌梗死经皮冠状动脉介入术患者的效果  

Effects of Esmolol combined with Tirofiban in treatment of patients with acute myocardial infarction undergoing percutaneous coronary intervention

作　　者：胡利辉 HU Lihui(Department of Pharmacy of the First People’s Hospital of Xiangfu District,Kaifeng 475000 Henan,China)

机构地区：[1]开封市祥符区第一人民医院药剂科,河南开封475000

出　　处：《中国民康医学》2025年第3期36-38,42,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察艾司洛尔联合替罗非班治疗急性心肌梗死经皮冠状动脉介入术(PCI)患者的效果。方法:回顾性分析2021年2月至2023年3月该院收治的86例急性心肌梗死患者的临床资料,按照治疗方法不同将其分为对照组和观察组各43例。两组均行PCI治疗,在此基础上,对照组予以替罗非班治疗,观察组在对照组基础上联合艾司洛尔治疗。比较两组临床疗效,治疗前后心功能指标[左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)]、心肌损伤标志物[肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)、N-末端脑钠肽前体(NT-proBNP)]、血清学指标[可溶性P选择素(sP-sel)、单核细胞趋化蛋白-1(MCP-1)、五聚素3(PTX3)]水平,以及不良反应发生率。结果:观察组治疗总有效率为95.35%(41/43),高于对照组的81.40%(35/43),差异有统计学意义(P<0.05);治疗后,两组LVESD、LVEDD水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组CK-MB、cTnI、NT-proBNP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);治疗后,两组sP-sel、MCP-1、PTX3水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:艾司洛尔联合替罗非班治疗急性心肌梗死PCI患者可提高治疗总有效率,降低心功能指标、心肌损伤标志物和血清学指标水平,效果优于单纯替罗非班治疗。Objective:To observe effects of Esmolol combined with Tirofiban in treatment of patients with acute myocardial infarction undergoing percutaneous coronary intervention(PCI).Methods:The clinical data of 86 patients with acute myocardial infarction admitted to this hospital from February 2021 to March 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,43 cases in each group.Both groups were treated with PCI.On this basis,the control group was treated with Tirofiban,while the observation group was treated with Esmolol on the basis of that of the control group.The clinical efficacy,the levels of cardiac function indexes[left ventricular end-systolic diameter(LVESD),left ventricular end-diastolic diameter(LVEDD)],myocardial injury markers[creatine kinase isoenzyme(CK-MB),cardiac troponin I(cTnI),N-terminal pro-brain natriuretic peptide(NT-proBNP)]and serological indexes[soluble P-selectin(sP-sel),monocyte chemoattractant protein-1(MCP-1),pentamer 3(PTX3)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 95.35%(41/43),which was higher than 81.40%(35/43)of the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of LVESD and LVEDD in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CK-MB,cTnI and NT-proBNP in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After the treatment,the levels of sP-sel,MCP-1 and PTX3 in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differen

关 键 词：艾司洛尔 替罗非班 急性心肌梗死 心功能 心肌损伤 不良反应 

分 类 号：R542.22[医药卫生—心血管疾病]