拉贝洛尔联合硫酸镁治疗妊娠期高血压患者的效果  

Effects of Labetalol combined with Magnesium sulfate in treatment of patients with gestational hypertension

作　　者：李晓娟 LI Xiaojuan(Department of Obstetrics and Gynecology of Henan Hongli Hospital,Xinxiang 453400 Henan,China)

机构地区：[1]河南宏力医院妇产科,河南新乡453400

出　　处：《中国民康医学》2025年第3期68-70,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察拉贝洛尔联合硫酸镁治疗妊娠期高血压患者的效果。方法:回顾性分析2022年3月至2023年3月该院收治的80例妊娠期高血压患者的临床资料,根据治疗方法不同将其分为对照组和观察组各40例。对照组给予硫酸镁治疗,观察组在对照组基础上联合拉贝洛尔治疗。比较两组治疗前后血压指标(收缩压、舒张压)水平、24 h尿蛋白(24hUP)水平、胎儿脐动脉收缩期峰值流速/舒张末期流速(S/D)水平,不良妊娠结局发生率,以及不良反应发生率。结果:治疗后,两组收缩压、舒张压水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组24hUP水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组S/D水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组剖宫产、胎盘早剥、胎儿呼吸窘迫、新生儿窒息等不良妊娠结局发生率比较,差异均无统计学意义(P>0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:拉贝洛尔联合硫酸镁治疗妊娠期高血压患者可降低其血压和尿蛋白水平,提高胎儿脐动脉血氧供应,效果优于单纯硫酸镁治疗。Objective:To observe effects of Labetalol combined with Magnesium sulfate in treatment of patients with gestational hypertension.Methods:The clinical data of 80 patients with gestational hypertension admitted to this hospital from March 2022 to March 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,40 cases in each group.The control group was treated with Magnesium sulfate,while the observation group was treated with Labetalol on the basis of that of the control group.The levels of blood pressure indexes(systolic blood pressure,diastolic blood pressure),24 h urine protein(24hUP)and fetal umbilical artery peak systolic velocity/end diastolic velocity(S/D),the incidence of adverse pregnancy outcomes,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the systolic blood pressure and diastolic blood pressure levels of the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The 24hUP levels of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).The S/D levels of the two groups were lower than those before the treatment,that in the observation group was lower than that in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse pregnancy outcomes such as cesarean section,placental abruption,fetal respiratory distress and neonatal asphyxia between the two groups(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Labetalol combined with Magnesium sulfate in the treatment of the patients with gestational hypertension can reduce t

关 键 词：妊娠期高血压 硫酸镁 拉贝洛尔 不良妊娠结局 血压 尿蛋白 胎儿脐动脉 

分 类 号：R714.2[医药卫生—妇产科学]