帕罗西汀联合坦度螺酮对比单药治疗抑郁症随机对照试验的安全性与有效性的meta分析  

Meta-analysis on the safety and efficacy of paroxetine combined with tandospirone in the randomized controlled trial of monotherapy in the treatment of depression

作　　者：张巍献 樊洁[2] 裴可灵 路淑淑 杨楹[1] ZHANG Weixian;FAN Jie;PEI Keling;LU Shushu;YANG Ying(Shandong Mental Health Center,Department of Children and Adolescents,Mental Health Center Affiliated to Shandong University,Shandong,Jinan 250014,China;Shandong Mental Health Center,Department of Pharmacy,Mental Health Center Affiliated to Shandong University,Shandong,Jinan 250014,China)

机构地区：[1]山东省精神卫生中心山东大学附属精神卫生中心儿童青少年科,山东济南250014 [2]山东省精神卫生中心山东大学附属精神卫生中心药学部,山东济南250014

出　　处：《中国医药科学》2025年第1期62-65,共4页China Medicine And Pharmacy

基　　金：山东省中医药科技项目(M-2022200);山东省医学会科研基金(YXH2020ZX059)。

摘　　要：目的研究帕罗西汀联合坦度螺酮对比单药治疗抑郁症的有效性和安全性。方法计算机检索国内外数据库,参考Cochrane评价手册进行meta分析。结果10篇随机对照研究被纳入本meta分析,共计701例患者。meta分析结果显示:与帕罗西汀单药治疗比较,治疗组(帕罗西汀联合坦度螺酮)能显著改善抑郁症状即汉密尔顿抑郁量表评分(P<0.0001)、汉密尔顿焦虑量表评分(P<0.00001)和有效率(P=0.0008);两组的副反应量表评分、不良反应发生率比较,差异均无统计学意义(P>0.05)。结论与帕罗西汀单药治疗相比,联合坦度螺酮治疗抑郁症可显著改善抑郁情绪,提高临床有效率,安全性无差异。Objective To investigate the efficacy and safety of paroxetine combined with tandospirone in the treatment of depression.Methods The domestic and foreign databases were searched by computer,and the meta-analysis was carried out with reference to Cochrane evaluation manual.Results A total of 10 randomized controlled trials involving 701 patients were included in this meta-analysis.It was shown by meta-analysis that:Compared with paroxetine monotherapy,the treatment group(paroxetine combined with tandospirone)could significantly alleviate the depressive symptoms,namely Hamilton depression scale score(P<0.0001),Hamilton anxiety scale score(P<0.00001)and response rate(P=0.0008).There were no statistically significant differences in treatment emergent symptom scale score and incidence of adverse reactions between the two groups(P>0.05).Conclusion Compared with paroxetine monotherapy,tandospirone combo therapy can significantly alleviate depressive mood,improve clinical efficacy rate and have no difference in safety.

关 键 词：帕罗西汀 坦度螺酮 抑郁症 META分析 

分 类 号：R969.4[医药卫生—药理学]