T细胞亚群、脂联素在原发性干燥综合征患者病情评估中的价值  

The diagnostic value of T cell subsets and adiponectin in assessment of-primary Sjögren syndrome patients

作　　者：陈孟 王春华[1] 李晓洁 CHEN Meng;WANG Chunhua;LI Xiaojie(Department of Rheumatology and Immunology,Heze Municipal Hospital,Shandong,Heze 274000,China)

机构地区：[1]菏泽市立医院风湿免疫科,山东菏泽274000

出　　处：《中国医药科学》2025年第1期79-82,共4页China Medicine And Pharmacy

基　　金：菏泽市立医院科技计划项目(2021YN25)。

摘　　要：目的分析T淋巴细胞亚群、脂联素(APN)对原发性干燥综合征(pSS)患者的影响,观察其在病情评估中的作用。方法回顾性分析菏泽市立医院风湿免疫科2022年1月至2024年1月收治的52例pSS患者的临床资料,将其纳入观察组,另选取同时期体检健康者52例为对照组。两组均接受T淋巴细胞亚群、APN检测,比较两组上述指标。检测pSS患者的病情相关指标,分析T淋巴细胞亚群、APN与免疫球蛋白M(IgM)、免疫球蛋白G(IgG)、类风湿因子(RF)相关性。结果观察组CD3^(+)指标与对照组比较,差异无统计学意义(P>0.05);观察组CD4^(+)、CD4^(+)/CD8^(+)水平低于对照组,CD8^(+)水平高于对照组,差异有统计学意义(P<0.05);观察组APN水平高于对照组,差异有统计学意义(P<0.05);Spearman相关性分析显示,CD4^(+)、CD4^(+)/CD8^(+)、APN与IgM、IgG呈正相关,与RF、干燥综合征疾病活动指数(ESSDAI)评分呈负相关;CD8^(+)与IgM、IgG呈负相关,与RF、ESSDAI评分呈正相关(P<0.05)。T淋巴细胞亚群、脂联素联合评估pSS的特异度为94.33%、灵敏度为95.33%(P<0.05)。结论pSS患者的CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、APN水平出现异常,且该指标与病情相关指标RF、IgM、IgG存在相关性。Objective To analyze the impacts of T lymphocyte subsets and adiponectin(APN)in patients with primary Sjögren syndrome(pSS)and observe their roles in disease assessment.Methods Clinical data of patients with pSS admitted to the Department of Rheumatology and Immunology of Heze Municipal Hospital from January 2022 to January 2024 were analyzed retrospectively,and they were divided into the observation group(n=52).Meanwhile,healthy individuals who underwent physical examinations during the same period were selected and divided into the control group(n=52).Both groups underwent testing for T lymphocyte subsets and APN,and the above indices were compared between the two groups.Disease-related indices in pSS patients were detected and the correlations with T lymphocyte subsets,APN,immunoglobulin M(IgM),immunoglobulin G(IgG),and rheumatoid factor(RF)were analyzed.Results There was no statistically significant difference in the CD3+index between the observation group and the control group,without statistically significant difference(P>0.05).The CD4^(+)and CD4^(+)/CD8^(+)levels in the observation group were lower than those in the control group,while the CD8^(+)index was higher than that in the control group,with statistically significant differences(P<0.05).The APN level in the observation group was higher than that in the control group,with statistically significant difference(P<0.05).Spearman correlation analysis showed that CD4^(+),CD4^(+)/CD8^(+),APN were positively correlated with IgM and IgG,and negatively correlated with RF and EULAR Sjögren syndrome disease activity index(ESSDAI)scores.CD8^(+)were negatively correlated with IgM and IgG,and positively correlated with RF and ESSDAI scores(P<0.05).The specificity and sensitivity of pSS evaluated by lymphocyte subpopulations and adiponectin combined were 94.33%and 95.33%,respectively(P<0.05).Conclusion The levels of CD4^(+),CD8^(+),CD4^(+)/CD8^(+),and APN in pSS patients are abnormal,and these indices are correlated with diseaserelated indices such as RF,IgM,and I

关 键 词：T淋巴细胞亚群 脂联素 原发性干燥综合征 诊断 

分 类 号：R593.2[医药卫生—内科学]