乌拉地尔注射液强化降压治疗高血压脑出血的临床效果  

Clinical effect of urapidil injection on hypertensive intracerebral hemorrhage

作　　者：袁松桂 周静仪 YUAN Songgui;ZHOU Jingyi(Department of Pharmacy,Zhuhai Hospital of Guangdong Provincial People′s Hospital(Zhuhai Jinwan Central Hospital),Guangdong Province,Zhuhai 519040,China)

机构地区：[1]广东省人民医院珠海医院(珠海市金湾中心医院)药剂科,广东省珠海市519040

出　　处：《临床合理用药》2025年第4期1-3,共3页Chinese Journal of Clinical Rational Drug Use

基　　金：国家自然科学基金项目(82160834)。

摘　　要：目的 观察乌拉地尔注射液强化降压治疗高血压脑出血的临床效果。方法 选择2023年1—12月广东省人民医院珠海医院收治的高血压脑出血患者80例开展临床实践研究,按照随机数字表法分为研究组和对照组,每组40例。研究组采用乌拉地尔注射液强化降压治疗,对照组采用乌拉地尔注射液常规治疗,治疗2周后比较2组临床疗效,治疗前后血浆黏度(PV)、纤维蛋白原(Fib)、脑血肿体积、血清炎性因子[肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)],治疗期间不良反应。结果 研究组总有效率为97.50%,高于对照组的85.00%(χ^(2)=3.914,P=0.048)。治疗2周后,2组PV、Fib低于治疗前,脑血肿体积小于治疗前,且研究组改善幅度大于对照组(P<0.01);2组血清TNF-α及hs-CRP水平低于治疗前,且研究组低于对照组(P<0.01)。研究组不良反应总发生率(7.50%)与对照组不良反应总发生率(5.00%)比较差异无统计学意义(χ^(2)=0.213,P=0.644)。结论 乌拉地尔注射液强化降压治疗高血压脑出血的临床效果较好,可改善患者脑血液流变学指标,减小脑血肿体积,调节炎性反应,改善预后。Objective To observe the clinical effect of urapidil injection on hypertensive intracerebral hemorrhage.Methods A total of 80 patients with hypertensive cerebral hemorrhage admitted to Zhuhai Hospital of Guangdong Provincial People′s Hospital from January to December 2023 were selected to carry out clinical practice study,and were divided into study group and control group according to random number table method,with 40 cases in each group.The study group received urapidil injection for intensive antihypertensive treatment,while the control group received urapidil injection for routine treatment.After 2 weeks of treatment,the clinical efficacy,plasma viscosity(PV),fibrinogen(Fib),volume of cerebral hematoma,serum inflammatory factors(TNF-α,hs-CRP)before and after treatment,adverse reactions during treatment of the 2 groups were compared.Results The total effective rate of the study group was 97.50%,and that of the control group was 85.00%(χ^(2)=3.914,P=0.048).After 2 weeks of treatment,PV and Fib in 2 groups were lower than before treatment,and the volume of cerebral hematoma was lower than before treatment,and the improvement in study group was greater than that in control group(P<0.01).Serum TNF-αand hs-CRP levels in 2 groups were lower than before treatment,and those in study group were lower than those in control group(P<0.01).There was no significant difference in the total incidence of adverse reactions between the study group(7.50%)and the control group(5.00%)(χ^(2)=0.213,P=0.644).Conclusion Urapidil injection has good clinical effect in the treatment of hypertensive intracerebral hemorrhage,which can improve cerebral hemorheology index,reduce cerebellar hematoma volume,regulate inflammatory response and improve prognosis.

关 键 词：高血压脑出血 乌拉地尔注射液 强化降压 血浆黏度 脑血肿 炎性因子 

分 类 号：R54[医药卫生—心血管疾病]