咽鼓管球囊扩张术联合鼓膜置管术治疗复发性分泌性中耳炎患者疗效及对咽鼓管功能、炎性因子和并发症的影响  

Curative effect of balloon eustachian tuboplasty combined with tympanostomy tube insertion and its influences on eustachian tube function,inflammatory factors and complications in patients with recurrent secretory otitis media Nantong First People's Hospital

作　　者：徐慧敏 高刚[1] 钱茂华[1] XU Huimin;GAO Gang;QIAN Maohua(Otolaryngology Head and Neck Surgery Department of Nantong First People's Hospital,Nantong,Jiangsu 226001,China)

机构地区：[1]江苏南通市第一人民医院耳鼻喉头颈外科,226001

出　　处：《中国中西医结合耳鼻咽喉科杂志》2025年第1期23-27,共5页Chinese Journal of Otorhinolaryngology in Integrative Medicine

摘　　要：目的 目的分析咽鼓管球囊扩张术(BET)联合鼓膜置管术(TTI)治疗复发性分泌性中耳炎(SOM)患者疗效及对咽鼓管功能、炎性因子和并发症的影响。方法 回顾性分析2020年1月~2023年1月来我院治疗复发性SOM患者98例。根据治疗方式分为联合组(例=54)和TTI组(例=44)。联合组行BET联合TTI治疗,TTI组行单纯TTI治疗。比较两组治疗效果及对咽鼓管功能[咽鼓管功能障碍症状评分量表(ETDQ-7)]、炎性因子[血小板活化因子(PAF)、白细胞介素-6(IL-6)和内皮素-1(ET-1)]表达水平及并发症的影响。结果 联合组临床有效率94.44%高于TTI组81.81%(P<0.05);治疗后,两组ETDQ-7组间、时间点及交互差异均有统计学意义(P<0.05),联合组各时间点ETDQ-7评分均显著低于TTI组(P<0.05);治疗后,两组PCT、IL-6及ET-1水平均有所下降,且联合组低于TTI组(P<0.05);联合组并发症发生率5.56%低于TTI组20.45%(P<0.05)。结论 BET联合TTI治疗复发性SOM患者疗效确切,有利于咽鼓管功能恢复,降低炎症反应,减少并发症发生率。Objective To analyze the curative effect of balloon eustachian tuboplasty(BET)combined with tympanostomy tube insertion(TTI)and its influences on eustachian tube function,inflammatory factors and complications in patients with recurrent secretory otitis media(SOM).Methods A total of 98 patients with recurrent SOM treated in the hospital were retrospectively analyzed between January 2020 and January 2023.According to different treatment methods,they were divided into combination group(n=54,BET+TTI)and TTI group(n=44,TTI).The curative effect,eustachian tube function[the seven-item Eustachian Tube Dysfunction Questionnaire(ETDQ-7)],inflammatory factors[platelet activating factor(PAF),interleukin-6(IL-6),endothelin-1(ET-1)]and complications in the two groups were compared.Results The clinical response rate of combination group was higher than that of TTI group(94.44%vs 81.81%,P<0.05).After treatment,there were significant differences in ETDQ-7 scores in between-group dimension,time points dimension and interaction dimension(P<0.05).ETDQ-7 scores in combination group were significantly lower than those in TTI group at different time points(P<0.05).After treatment,levels of PCT,IL-6 and ET-1 in both groups were decreased,which were lower in combination group than TTI in group(P<0.05).The incidence of complications in combination group was lower than that in TTI group(5.56%vs 20.45%,P<0.05).Conclusion The curative effect of BET combined with TTI is significant in patients with recurrent SOM,which is beneficial to recover eustachian tube function,reduce inflammatory response and incidence of complications.

关 键 词：复发性分泌性中耳炎 咽鼓管球囊扩张术 鼓膜置管术 咽鼓管功能 炎性因子 并发症 

分 类 号：R76[医药卫生—耳鼻咽喉科]