宏基因组二代测序诊断儿童造血干细胞移植后毛霉菌病3例  

Diagnosis of mucormycosis in three children following hematopoietic stem cell transplantation using metagenomic next-generation sequencing

作　　者：李越[1] 周小辉 王晓东[1] 王春静[1] 曹科[2] 刘四喜[1] LI Yue;ZHOU Xiao-Hui;WANG Xiao-Dong;WANG Chun-Jing;CAO Ke;LIU Si-Xi(Department of Hematology and Oncology,Shenzhen Children's Hospital,Shenzhen,Guangdong 518000,China)

机构地区：[1]深圳市儿童医院血液肿瘤科,广东深圳518000 [2]深圳市儿童医院检验科,广东深圳518000

出　　处：《中国当代儿科杂志》2025年第2期219-224,共6页Chinese Journal of Contemporary Pediatrics

基　　金：广东省高水平临床重点专科(深圳市配套建设经费)(SZGSP012);深圳市医学重点学科建设经费(SZXK034);深圳市医疗卫生“三名工程”(SZSM201512033)。

摘　　要：该文报道3例儿童造血干细胞移植术后合并毛霉菌病的临床特点和诊治经过并对相关文献进行复习。3例患儿以胸痛为首发症状,均经宏基因组二代测序早期明确为毛霉菌感染,2例治疗后痊愈,1例因播散性感染死亡。宏基因组二代测序推动了毛霉菌病的早期诊断和治疗,降低病死率,联合手术治疗是改善预后的重要手段。This article reports the clinical characteristics and treatment processes of three cases of mucormycosis occurring after hematopoietic stem cell transplantation in children,along with a review of relevant literature.All three patients presented with chest pain as the initial symptom,and metagenomic next-generation sequencing(mNGS)confirmed the mucycete infection early in all cases.Two patients recovered after treatment,while one succumbed to disseminated infection.mNGS has facilitated early diagnosis and treatment,reducing mortality rates.Additionally,surgical intervention is an important strategy for improving the prognosis of this condition.

关 键 词：毛霉菌病 造血干细胞移植 宏基因组二代测序 儿童 

分 类 号：R457.7[医药卫生—治疗学] R725.1[医药卫生—临床医学]