N6-腺苷酸甲基化和铁死亡在儿童变应性鼻炎-哮喘综合征中的研究进展  

Research progress on N6-methyladenosine and ferroptosis in childhood combined allergic rhinitis and asthma syndrome

作　　者：李婧怡 李昱剑 赖晟琳(综述) 阚璇(审校)[1] LI Jing-Yi;LI Yu-Jian;LAI Sheng-Lin;KAN Xuan(Department of Pediatrics,General Hospital of Tianjin Medical University,Tianjin 300052,China)

机构地区：[1]天津医科大学总医院儿科,天津300052 [2]天津医科大学公共卫生学院,天津300000

出　　处：《中国当代儿科杂志》2025年第2期242-247,共6页Chinese Journal of Contemporary Pediatrics

摘　　要：变应性鼻炎-哮喘综合征(combined allergic rhinitis and asthma syndrome,CARAS)是儿童时期常见的慢性气道炎症性疾病之一。随着表观遗传学的发展,对CARAS的研究逐渐从蛋白质层面延伸至转录、转录后调控等微观层面。N6-腺苷酸甲基化(N6-methyladenosine,m6A)和铁死亡(ferroptosis)作为近年来十分有研究前景的热点,在肿瘤、生长发育、变应性疾病等方面均发挥着关键作用。该文旨在总结m6A和铁死亡的特点,以及它们在儿童CARAS的发生发展中的作用,从而为儿童CARAS的诊治提供新的思路和策略。Combined allergic rhinitis and asthma syndrome(CARAS)is one of the common chronic airway inflammatory diseases in children.With the development of epigenetics,research on CARAS has gradually extended from protein levels to molecular levels,such as transcription and post-transcriptional regulation.N6-methyladenosine(m6A)methylation and ferroptosis have emerged as promising research hotspots in recent years,playing crucial roles in tumors,growth and development,and allergic diseases.This paper aims to summarize the characteristics of m6A and ferroptosis,along with their roles in the onset and progression of CARAS in children,thereby providing new insights and strategies for the diagnosis and treatment of childhood CARAS.

关 键 词：变应性鼻炎-哮喘综合征 N6-腺苷酸甲基化 铁死亡 变应性鼻炎 变应性哮喘 儿童 

分 类 号：R76[医药卫生—耳鼻咽喉科]